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| Nomenclature |
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Symbol:
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Pax6tm2Pgr
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Name:
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paired box gene 6;
targeted mutation 2, Peter Gruss
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MGI ID: |
MGI:1934348 |
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Synonyms: |
Pax6flox, Pax6lox |
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Gene:
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Pax6
Location:
Chr2:105668896-105703160 bp, + strand
Genetic Position: Chr2,
55.31 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:65765
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of loxP sequences flanking the exons encoding the amino terminus of the protein, including the initiator methionine and most of the paired domain. A frt-flanked neomycin cassette in intron 6 was removed via Flp-mediated recomination to create the final allele. These insertions had no effect on the normal function of the allele. (J:65765)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pax6 Mutation:
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33 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: juvenile glaucoma in mice heterozygous for Pax6tm2Pgr and hemizygous for Tg(Pax6-cre,GFP)1Pgr (J:163191).
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| References |
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Original: |
J:65765
Ashery-Padan R et al.,
"Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye"
Genes Dev 2000 Nov 1;14(21):2701-11
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All: |
21 reference(s)
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Analysis Tools
