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| Nomenclature |
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Symbol:
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Trp63tm1Fmc
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Name:
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transformation related protein 63;
targeted mutation 1, Frank McKeon
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MGI ID: |
MGI:1934269 |
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Synonyms: |
p63-, p63 KO, Tp63- |
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Gene:
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Trp63
Location:
Chr16:25683763-25892102 bp, + strand
Genetic Position: Chr16,
17.37 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:54637
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 6, 7, 8, encoding sequences corresonding to the DNA-binding domain, and the intervening introns were replaced by a neomycin gene. (J:54637)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Trp63 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:54637
Yang A et al.,
"p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development."
Nature 1999 Apr 22;398(6729):714-8
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All: |
24 reference(s)
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Analysis Tools
