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| Nomenclature |
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Symbol:
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Notch1tm1Agt
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Name:
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notch 1;
targeted mutation 1, Michael Aguet
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MGI ID: |
MGI:1933835 |
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Synonyms: |
floxNotch1, N1flox, Notch1F, Notch1flox, Notch1lox |
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Gene:
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Notch1
Location:
Chr2:26457903-26516663 bp, - strand
Genetic Position: Chr2,
18.91 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:55400
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Parent Cell Line:
| GS1 (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of loxP sites flanking the first coding exon of the gene. This mutation had no effect on the normal function of the gene. An adjacent loxP flanked neomycin cassette was removed by Cre-mediated recombination in ES cells prior to production of chimeric animals. (J:55400)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Notch1 Mutation:
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31 strains or lines available |
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| References |
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Original: |
J:55400
Radtke F et al.,
"Deficient T cell fate specification in mice with an induced inactivation of Notch1."
Immunity 1999 May;10(5):547-58
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All: |
72 reference(s)
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Analysis Tools
