Ifnar1<tm1Agt> Targeted Allele Detail MGI Mouse (MGI:1930950)

Ifnar1^tm1Agt
Targeted Allele Detail

Nomenclature

Symbol:	Ifnar1^tm1Agt
Name:	interferon (alpha and beta) receptor 1; targeted mutation 1, Michel Aguet
MGI ID:	MGI:1930950
Synonyms:	A^-, A129, A 129, IFN-alpha/betaR-, IFN-alphabetaR-, IFN-alpha/betaR⁰, IFN-alpha/betaR/A129, IFN-alphabeta-R KO, IFN Alpha Ro/o, IFNAR^-, IFNAR(0), Ifnar1-, IFN-IR^-, IFN-IR KO, IFNR^-, IFNRA1,-., IFNRI -, IFNR KO, IFN type I receptor
Gene:	Ifnar1 Location: Chr16:91485238-91507441 bp, + strand Genetic Position: Chr16, 52.98 cM

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:36115
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (knock-out)
Mutation:		Insertion
		A neomycin cassette was inserted into exon 3 at a position corresponding to amino acid 88. (J:36115, J:96036)
Inheritance:		Recessive

Phenotypes

View phenotypes for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Ifnar1 Mutation:	7 strains or lines available

References

Original:	J:36115 Muller U et al., "Functional role of type I and type II interferons in antiviral defense." Science 1994 Jun 24;264(5167):1918-21
All:	398 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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