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| Nomenclature |
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Symbol:
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CrebbpGt(U-San)112Imeg
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Name:
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CREB binding protein;
gene trap 112, Institute of Molecular Embryology and Genetics
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MGI ID: |
MGI:1928775 |
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Synonyms: |
CBP+/- |
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Gene:
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Crebbp
Location:
Chr16:4084048-4213404 bp, - strand
Genetic Position: Chr16,
2.4 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:53370
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Gene trapped |
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Mutation: | |
Insertion of gene trap vector |
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Mutation details: Insertion of the gene trap vector pU-San into an intron of the Crebbp gene located between the exons containing nucleotides 3064-3253 and 3254-3373. Mice carrying this allele express a 121 kd truncated form of the Crebbp protein. (J:53370)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Crebbp Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:53370
Oike Y et al.,
"Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism."
Hum Mol Genet 1999 Mar;8(3):387-96
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All: |
4 reference(s)
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Analysis Tools
