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| Nomenclature |
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Symbol:
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C4btm1Crr
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Name:
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complement component 4B (Chido blood group);
targeted mutation 1, Michael C Carroll
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MGI ID: |
MGI:1889070 |
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Synonyms: |
C4- |
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Gene:
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C4b
Location:
Chr17:34728380-34743882 bp, - strand
Genetic Position: Chr17,
18.29 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:30152
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment corresponding to 987 nucleotides of coding sequence (exons 23-29) was replaced with a neomycin selection cassette. ELISA assays on serum derived from homozygous mice demonstrated that no detectable protein is produced from this allele.(J:64282)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:30152
Wessels MR et al.,
"Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity."
Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11490-4
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All: |
67 reference(s)
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Analysis Tools
