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| Nomenclature |
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Symbol:
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Nogtm1Amc
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Name:
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noggin;
targeted mutation 1, Andrew P McMahon
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MGI ID: |
MGI:1862000 |
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Synonyms: |
Nog-, Nog9E, noggin-, NogginlacZ |
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Gene:
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Nog
Location:
Chr11:89300638-89302332 bp, - strand
Genetic Position: Chr11,
54.34 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:47724
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: Gene targeting generated a null allele by fusing the first 10 amino acids of coding sequence in-frame to the lacZ gene. The remainder of the coding sequence and some of the 3' flanking sequence of the gene were deleted. Ectopic expression of the resulting transcript was noted. (J:47724)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:47724
McMahon JA et al.,
"Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite."
Genes Dev 1998 May 15;12(10):1438-52
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All: |
44 reference(s)
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Analysis Tools
