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| Nomenclature |
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Symbol:
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Il2rgtm1Cgn
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Name:
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interleukin 2 receptor, gamma chain;
targeted mutation 1, University of Cologne
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MGI ID: |
MGI:1861947 |
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Synonyms: |
cgamma-, gamma-, gammac-, gc-, Il2rg-, IL-2Rgamma- |
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Gene:
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Il2rg
Location:
ChrX:101264378-101268255 bp, - strand
Genetic Position: ChrX,
43.9 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:22521
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Insertion of a neomycin resistance cassette flanked by lox P sites, followed by homologous recombination and cre-mediated deletion, resulted in the excision of exons 2 - 6 of the gene. These exons encode the extracellular and transmembrane domains of the protein. (J:22521)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:22521
DiSanto JP et al.,
"Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain."
Proc Natl Acad Sci U S A 1995 Jan 17;92(2):377-81
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All: |
90 reference(s)
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Analysis Tools
