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| Nomenclature |
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Symbol:
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Fastm1Osa
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Name:
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Fas (TNF receptor superfamily member 6);
targeted mutation 1, Osaka University Medical School
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MGI ID: |
MGI:1861923 |
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Synonyms: |
Fas-, Tnfrsf6tm1Osa |
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Gene:
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Fas
Location:
Chr19:34290659-34327770 bp, + strand
Genetic Position: Chr19,
29.48 cM
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Histopathology of Fas-deficient mice.
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64296
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A BetaGal-neo cassette was used to delete a portion of exon 9, which codes for the cytoplasmic domain essential for Fas-mediated apoptosis. Northern blot analysis revealed the expression of a truncated mRNA, representing transcripts from exons 1 though 8 in the thymus, liver, and heart. Immunoprecipitation analysis showed an absence of the wild-type protein as well as a faint presence of what the authors speculated to be a non-functional Tnfrsf6-BetaGal fusion protein. (J:64296)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:64296
Adachi M et al.,
"Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver."
Nat Genet 1995 Nov;11(3):294-300
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All: |
21 reference(s)
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Analysis Tools
