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| Nomenclature |
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Symbol:
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Itgb2tm2Bay
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Name:
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integrin beta 2;
targeted mutation 2, Baylor College of Medicine
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MGI ID: |
MGI:1861705 |
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Synonyms: |
beta2-, CD18-, CD18 null, Itgb2- |
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Gene:
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Itgb2
Location:
Chr10:77530252-77565708 bp, + strand
Genetic Position: Chr10,
39.72 cM
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Skeletal abnormalities in Itgb2tm2Bay/Itgb2tm2Bay mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:13599
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette disrupted the 5' boundary of exon 3. No protein was synthesized from this allele. (J:48542)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Trans heterozgous mice (Itgb2tm1Bay / Itgb2tm2Bay) on a mixed background that includes the strain PL/J and trans heterozygous mice on a congenic PL/J background display Phenotypic Similarity to Human Syndrome: Psoriasis. However, mice on backgrounds that do not include PL/J do not display psoriasis. (J:32126, J:84126)
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| References |
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Original: |
J:13599
Wilson RW et al.,
"Gene targeting yields a CD18-mutant mouse for study of inflammation."
J Immunol 1993 Aug 1;151(3):1571-8
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All: |
90 reference(s)
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Analysis Tools
