|
|
| Nomenclature |
|
Symbol:
|
Adrb2tm1Bkk
|
|
Name:
|
adrenergic receptor, beta 2;
targeted mutation 1, Brian K Kobilka
|
|
MGI ID: |
MGI:1859675 |
|
Synonyms: |
Adrb2-, beta2AR-, Beta2-AR, Beta2-KO |
|
Gene:
|
Adrb2
Location:
Chr18:62177817-62179959 bp, - strand
Genetic Position: Chr18,
35.1 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:55552
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A neomycin selection cassette was inserted into the sequence encoding the fourth transmembrane segment. This mutation is predicted to eliminate expression of a functional receptor. Ligand binding experiments confirmed that no functional receptor was expressed in the lung of homozygous mice. (J:55552)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:55552
Chruscinski AJ et al.,
"Targeted disruption of the beta2 adrenergic receptor gene."
J Biol Chem 1999 Jun 11;274(24):16694-700
|
|
All: |
61 reference(s)
|
|
Analysis Tools
