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| Nomenclature |
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Symbol:
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Fancctm1Mgo
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Name:
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Fanconi anemia, complementation group C;
targeted mutation 1, Markus Grompe
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MGI ID: |
MGI:1858041 |
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Synonyms: |
facdeltaexon 9 |
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Gene:
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Fancc
Location:
Chr13:63304709-63497278 bp, - strand
Genetic Position: Chr13,
32.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61512
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a genomic DNA fragment containing exon 9. RT-PCR analysis demonstrated that an abnormal transcript lacking only exon 9 was produced from this allele; however, no functional protein can be expressed from this mutant transcript. (J:61512)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fancc Mutation:
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37 strains or lines available |
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| References |
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Original: |
J:61512
Whitney MA et al.,
"Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene."
Blood 1996 Jul 1;88(1):49-58
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All: |
10 reference(s)
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Analysis Tools
