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| Nomenclature |
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Symbol:
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Grm7tm1Nak
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Name:
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glutamate receptor, metabotropic 7;
targeted mutation 1, Shigetada Nakanishi
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MGI ID: |
MGI:1857984 |
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Synonyms: |
mGluR7- |
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Gene:
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Grm7
Location:
Chr6:110645581-111567230 bp, + strand
Genetic Position: Chr6,
51.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:52411
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a part of the first coding exon comprising the 5' untranslated region and the first 164 amino acids of the protein. In situ hybridization of sagittal and coronal sections of the brain using an antisense probe corresponding to the first coding exon of the targeted gene showed no detectable mRNA expression in homozygous mutant mice. (J:52411)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Grm7 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:52411
Masugi M et al.,
"Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion."
J Neurosci 1999 Feb 1;19(3):955-63
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All: |
8 reference(s)
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Analysis Tools
