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| Nomenclature |
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Symbol:
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Atp2b2tm1Ges
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Name:
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ATPase, Ca++ transporting, plasma membrane 2;
targeted mutation 1, Gary E Shull
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MGI ID: |
MGI:1857876 |
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Synonyms: |
Pmca2 - |
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Gene:
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Atp2b2
Location:
Chr6:113745669-114042613 bp, - strand
Genetic Position: Chr6,
52.85 cM
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Atp2b2tm1Ges/Atp2b2tm1Ges mice exhibit an unsteady gait and difficulty in maintaining balance
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:48863
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 19, which encodes transmembrane domains essential for transport activity. Northern blot analysis demonstrated that no detectable transcript was produced from this allele in brain of homozygous mice. (J:48863)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:48863
Kozel PJ et al.,
"Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2."
J Biol Chem 1998 Jul 24;273(30):18693-6
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All: |
10 reference(s)
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Analysis Tools
