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| Nomenclature |
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Symbol:
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Acox1tm1Jkr
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Name:
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acyl-Coenzyme A oxidase 1, palmitoyl;
targeted mutation 1, Janardan K Reddy
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MGI ID: |
MGI:1857811 |
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Synonyms: |
ACOX-, Acox1-, AOX- |
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Gene:
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Acox1
Location:
Chr11:116171888-116199045 bp, - strand
Genetic Position: Chr11,
80.96 cM
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Hepatocellular alterations in liver of Acox1tm1Jkr/Acox1tm1Jkr mice
Show the 7 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:35794
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Parent Cell Line:
| BK4 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.3kb SstI-BamHI segment containing exons 8 and 9 was replaced with a neomycin selection cassette. The 3.8-kb transcript is undetectable in RNA derived from the livers of homozygous mice by Northern blot. Western blots and enzymatic assays confirmed the absence of functional protein in homozygous mice. (J:35794)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Acox1 Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:35794
Fan CY et al.,
"Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene."
J Biol Chem 1996 Oct 4;271(40):24698-710
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All: |
15 reference(s)
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Analysis Tools
