Slc11a1r
Spontaneous Allele Detail
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| Nomenclature |
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Symbol:
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Slc11a1r
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Name:
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solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1;
host resistance (Bcg/Ity/Lsh)
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MGI ID: |
MGI:1857756 |
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Synonyms: |
Bcgr, Lshr, Nramp1G169, Nramp1Gly169, Slc11a1Bcg, Slc11a1Ity, Slc11a1Lsh |
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Gene:
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Slc11a1
Location:
Chr1:74375203-74386062 bp, + strand
Genetic Position: Chr1,
38.54 cM
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Mutation
origin |
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Strain of Origin:
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multiple strains
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: This allele is associated with natural resistance to infection with diverse pathogens, including some Mycobacterium species, Salmonella typhimurium, and Leishmania donovani. A G at nucleotide position 783 of this allele produces a protein with Gly at position 105 within the second predicted transmembrane domain. The protein also has Gly at position 169 within the fourth predicted transmembrane domain. (J:4762, J:20139, J:35004)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc11a1 Mutation:
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3 strains or lines available |
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Notes |
It has been suggested that multiple genes may be involved in the control of mycobacterial infections in inbred mice (J:17780); the early phase of these infections is controlled in Slc11a1r strains, but later phases are not (J:28278). Slc11a1 plays differing roles with respect to infection with Toxoplasma gondii, depending on inoculum potency, route of infection, and genetic background. This probably reflects pleitropic effects of macrophage products stimulated by differential priming rather than direct toxoplasmicidal action of the macrophages (J:19600). Slc11a1 had no effect on susceptibility to infection with Serpula (Treponema) hyodysenteriae (J:17927).
Resistant strains include 129X1/SvJ, 129S4/SvJae, DBA/2J, C57L/J, SJL/J, A/J, NZB/BlNJ, CBA/J, NOD/Lt, SWR/J, Mus spretus.
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| References |
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Original: |
J:24667
Webster LT,
"Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding"
J Exp Med 1933;57():793-843
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All: |
56 reference(s)
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Analysis Tools
