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| Nomenclature |
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Symbol:
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Htttm1Szi
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Name:
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huntingtin;
targeted mutation 1, Scott Zeitlin
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MGI ID: |
MGI:1857722 |
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Synonyms: |
Hdh-, Hdhprex1 |
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Gene:
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Htt
Location:
Chr5:34761740-34912534 bp, + strand
Genetic Position: Chr5,
17.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29267
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a 2.8 kb fragment of the gene, which included the 5' flanking sequence, the entire first exon, and 0.6 kb of the 3' flanking intron. (J:29267)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Htt Mutation:
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40 strains or lines available |
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| References |
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Original: |
J:29267
Zeitlin S et al.,
"Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue."
Nat Genet 1995 Oct;11(2):155-63
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All: |
9 reference(s)
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Analysis Tools
