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| Nomenclature |
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Symbol:
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Alx4tm1Rwi
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Name:
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aristaless-like homeobox 4;
targeted mutation 1, Ronald Wisdom
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MGI ID: |
MGI:1857484 |
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Synonyms: |
Alx-4-, Alx-4tm1qw |
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Gene:
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Alx4
Location:
Chr2:93642384-93681339 bp, + strand
Genetic Position: Chr2,
51.62 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43769
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into sequences encoding the recognition helix of the homeobox domain. Western blot analysis on nuclear extracts derived from E10.5 embryos indicated that the protein is absent in homozygous mice. (J:43769)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Alx4 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:43769
Qu S et al.,
"Polydactyly and ectopic ZPA formation in Alx-4 mutant mice."
Development 1997 Oct;124(20):3999-4008
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All: |
5 reference(s)
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Analysis Tools
