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| Nomenclature |
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Symbol:
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Baxtm1Sjk
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Name:
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BCL2-associated X protein;
targeted mutation 1, Stanley J Korsmeyer
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MGI ID: |
MGI:1857429 |
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Synonyms: |
Bax- |
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Gene:
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Bax
Location:
Chr7:45461695-45466898 bp, - strand
Genetic Position: Chr7,
29.32 cM, cytoband B5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29253
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced exons 2 through 4 and part of exon 5, which encode sequences that correspond to the two BCL2 homology domains BH1 and BH2. Immunoblots did not detect the endcoded protein in tissue lysates derived from homozygous mice. (J:29253)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:29253
Knudson CM et al.,
"Bax-deficient mice with lymphoid hyperplasia and male germ cell death."
Science 1995 Oct 6;270(5233):96-9
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All: |
243 reference(s)
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Analysis Tools
