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| Nomenclature |
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Symbol:
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Trp53tm1Tyj
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Name:
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transformation related protein 53;
targeted mutation 1, Tyler Jacks
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MGI ID: |
MGI:1857263 |
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Synonyms: |
p53-, p53delta, p53KO, p53null, Trp53-, Trp53KO |
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Gene:
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Trp53
Location:
Chr11:69580359-69591873 bp, + strand
Genetic Position: Chr11,
42.83 cM, cytoband B2-C
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Persistent hyperplastic primary vitreous (PHPV) in Cdkn2atm1Cjs/Cdkn2atm1Cjs mice is p53 independent
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:17728
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced 40% of the coding sequences beginning with exon 2 (upstream of the translation start site) and extending into exon 6. (J:17728)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This mutant allele was produced by a targeted neo insertion into the Trp53 locus. Homozygotes show no visible phenotype but develop tumors at 3-6 months of age. Heterozygotes develop tumors at 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome (OMIM 151623), a form of familial breast cancer with mutations in TRP53 (J:16022)(J:16023) A specific human mutation found in hepatocellular carcinomas caused by hepatitis B infection or by aflatoxin exposure has been created in a mouse model, resulting in a similar gene product (J:27363).
Phenotypic Similarity to Human Syndrome: Glioblastoma Multiforme (J:149662)
Phenotypic Similarity to Human Syndrome: Astrocytoma (J:64364 and J:134611)
Phenotypic Similarity to Human Syndrome: activated B-cell diffuse large-cell lymphoma in mice hemizygous for Tg(Ly6e-MALT1)#Isg and homozygous for this allele (ABC-DLBCL, J:185590)
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| References |
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Original: |
J:17728
Jacks T et al.,
"Tumor spectrum analysis in p53-mutant mice."
Curr Biol 1994 Jan 1;4(1):1-7
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All: |
649 reference(s)
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Analysis Tools
