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| Nomenclature |
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Symbol:
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Stat5atm1Mam
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Name:
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signal transducer and activator of transcription 5A;
targeted mutation 1, Lothar Hennighausen
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MGI ID: |
MGI:1857249 |
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Synonyms: |
Stat5a- |
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Gene:
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Stat5a
Location:
Chr11:100859351-100885169 bp, + strand
Genetic Position: Chr11,
63.77 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64278
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The promoter sequence, an untranslated exon, and two coding exons were replaced by a neomycin selection cassette. Western blot analysis of extracts immunoprecipitated from mammary tissue of homozygous mutant mice showed an absence of encoded protein. (J:64278)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:64278
Liu X et al.,
"Stat5a is mandatory for adult mammary gland development and lactogenesis."
Genes Dev 1997 Jan 15;11(2):179-86
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All: |
25 reference(s)
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Analysis Tools
