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| Nomenclature |
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Symbol:
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Stat4tm1Gru
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Name:
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signal transducer and activator of transcription 4;
targeted mutation 1, Michael J Grusby
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MGI ID: |
MGI:1857248 |
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Synonyms: |
Stat4- |
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Gene:
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Stat4
Location:
Chr1:52008244-52107184 bp, + strand
Genetic Position: Chr1,
26.67 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:34059
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The exon encoding amino acids 263 through 314 was disrupted by the insertion of a neomycin selection cassette. The encoded protein was undetectable in the thymi and lymph nodes of homozygous mutant mice by immunoblot analysis. (J:34059)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:34059
Kaplan MH et al.,
"Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice."
Nature 1996 Jul 11;382(6587):174-7
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All: |
136 reference(s)
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Analysis Tools
