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| Nomenclature |
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Symbol:
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Abcb4tm1Bor
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Name:
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ATP-binding cassette, sub-family B (MDR/TAP), member 4;
targeted mutation 1, Piet Borst
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MGI ID: |
MGI:1857236 |
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Synonyms: |
mdr2-, mdr2neo1, Pgy2tm1Bor |
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Gene:
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Abcb4
Location:
Chr5:8893721-8959225 bp, + strand
Genetic Position: Chr5,
3.43 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:15531
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 1 and 2. The translation initiation site is in exon 2. RNase proteiction assays indicated that mutant truncated transcripts are produced from this allele that contain exons 3-6 or 4-6. (J:15531)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:15531
Smit JJ et al.,
"Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease."
Cell 1993 Nov 5;75(3):451-62
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All: |
47 reference(s)
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Analysis Tools
