Fcer1gtm1Rav
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Fcer1gtm1Rav
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Name:
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Fc receptor, IgE, high affinity I, gamma polypeptide;
targeted mutation 1, Jeffrey V Ravetch
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MGI ID: |
MGI:1857165 |
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Synonyms: |
Fcepsilonrgamma-, Fcer1gtm1, Fcer1gtm1Ra, Fcerg1tm1, FcgammaR-, FcR-, FcRg-, FcR gamma-, FcRgamma-, FcRgammac-, FcRgamma-chain-, FcRgammanl, FcRKO, gamma- |
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Gene:
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Fcer1g
Location:
Chr1:171229572-171234365 bp, - strand
Genetic Position: Chr1,
79.23 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39248
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette was inserted into exon 2, creating a new stop codon 239 bp downstream of the integration site. RT-PCR analysis on RNA isolated from activated macrophages, mast cells and NK cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on lysates derived from activated macrophages, mast cells and NK cells of homozygous mice confirmed that no protein is encoded by this allele. (J:39248)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:39248
Takai T et al.,
"FcR gamma chain deletion results in pleiotrophic effector cell defects."
Cell 1994 Feb 11;76(3):519-29
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All: |
234 reference(s)
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Analysis Tools
