|
|
| Nomenclature |
|
Symbol:
|
Cd4tm1Mak
|
|
Name:
|
CD4 antigen;
targeted mutation 1, Tak Mak
|
|
MGI ID: |
MGI:1857144 |
|
Synonyms: |
CD4-, CD40, CD4 KO |
|
Gene:
|
Cd4
Location:
Chr6:124864692-124888221 bp, - strand
Genetic Position: Chr6,
59.17 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:68957
|
|
Parent Cell Line:
| D3 (ES Cell) |
|
Strain of Origin:
|
129S2/SvPas
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A neomycin resistance cassette was inserted into exon 5. Flow cytometry analysis demonstrated that the protein was absent from the cell surface of thymocytes and lymph node cells in homozygous mice. (J:68957)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:68957
Rahemtulla A et al.,
"Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4."
Nature 1991 Sep 12;353(6340):180-4
|
|
All: |
170 reference(s)
|
|
Analysis Tools
