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| Nomenclature |
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Symbol:
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B2mtm1Unc
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Name:
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beta-2 microglobulin;
targeted mutation 1, University of North Carolina
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MGI ID: |
MGI:1857133 |
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Synonyms: |
b2mnull, beta2M-, beta2m0, beta2-m-KO, beta2MKO, beta2mnull, beta2mo, beta2mtm1Unc, I0, MHC-I- |
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Gene:
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B2m
Location:
Chr2:122147686-122153083 bp, + strand
Genetic Position: Chr2,
60.55 cM, cytoband F1-F3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:65612
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Insertion of a neomycin-resistance gene into the second exon. (J:65612)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:51450)
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| References |
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Original: |
J:65612
Koller BH et al.,
"Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination."
Proc Natl Acad Sci U S A 1989 Nov;86(22):8932-5
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All: |
381 reference(s)
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Analysis Tools
