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| Nomenclature |
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Symbol:
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Adatm1Mw
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Name:
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adenosine deaminase;
targeted mutation 1, Maki Wakamiya
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MGI ID: |
MGI:1857117 |
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Synonyms: |
Ada-, adam1 |
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Gene:
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Ada
Location:
Chr2:163726584-163750239 bp, - strand
Genetic Position: Chr2,
84.44 cM, cytoband H3
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Hepatocyte abnormalities in Adatm1Mw/Adatm1Mw mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:25085
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 5. Activity assays demonstrated that no functional protein was made from this allele in homozygous mice. (J:25085)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:25085
Wakamiya M et al.,
"Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice."
Proc Natl Acad Sci U S A 1995 Apr 25;92(9):3673-7
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All: |
33 reference(s)
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Analysis Tools
