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| Nomenclature |
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Symbol:
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Invsinv
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Name:
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inversin;
inversion of embryonic turning
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MGI ID: |
MGI:1856915 |
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Synonyms: |
inv |
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Gene:
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Invs
Location:
Chr4:48279760-48431954 bp, + strand
Genetic Position: Chr4,
26.11 cM, cytoband B
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutations: | |
Insertion, Intragenic deletion, Duplication |
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Mutation details: The inv mutation was caused by a transgene insertion mutagenic event that resulted in a small duplication and a 47-kb deletion. This deletion eliminated exons 3-11, causing a frameshift in the remaining coding segment. (J:50117, J:81042)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This is the only situs inversus mutation in which the asymmetries occur 100% of the time. Transgenic complementation studies demonstrated that the Invs gene alone corrects the inv mutation, and should be considered the gene responsible for the inv phenotype (J:49759, J:50117).
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| References |
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Original: |
J:4934
Yokoyama T et al.,
"Reversal of left-right asymmetry: a situs inversus mutation [see comments]"
Science 1993 Apr 30;260(5108):679-82
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All: |
29 reference(s)
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Analysis Tools
