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| Nomenclature |
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Symbol:
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Foxe3dyl
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Name:
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forkhead box E3;
dysgenetic lens
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MGI ID: |
MGI:1856851 |
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Synonyms: |
dyl |
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Gene:
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Foxe3
Location:
Chr4:114925147-114926013 bp, - strand
Genetic Position: Chr4,
52.73 cM, cytoband C7
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Mutation
origin |
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Strain of Origin:
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BALB/cLiA
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: Two missense mutations in the sequences encoding the forkhead domain were shown to cosegregate with the dyl phenotype: two C to T transitions at positions 277 and 293 that change codons 93 and 98 from phenylalanine to leucine and serine respectively. These mutations are in a region of the protein thought to be critical for DNA binding. (J:59880)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:6131
Sanyal S et al.,
"Dysgenetic lens (dyl)--a new gene in the mouse."
Invest Ophthalmol Vis Sci 1979 Jun;18(6):642-5
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All: |
8 reference(s)
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Analysis Tools
