|
|
| Nomenclature |
|
Symbol:
|
Glrbspa
|
|
Name:
|
glycine receptor, beta subunit;
spastic
|
|
MGI ID: |
MGI:1856363 |
|
Synonyms: |
spa |
|
Gene:
|
Glrb
Location:
Chr3:80843599-80913660 bp, - strand
Genetic Position: Chr3,
35.71 cM, cytoband E3-F1
|
|
Mutation
origin |
|
Strain of Origin:
|
Not Specified
|
|
Mutation
description |
|
Allele
Type: | |
Spontaneous |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The mutation in the spastic mouse is an insertion of a 7.1 kilobase LINE-1 element within intron 6 of the gene. Glrb mRNA is markedly reduced throughout brains of homozygous mice, and was shown to be aberrantly spliced. (J:18530, J:21071, J:190416)
|
|
Inheritance: | |
Recessive |
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Analysis Tools
