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GO Annotations Graph
 Symbol
Name
ID
Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Fri Jan 17 13:56:29 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0046875ephrin receptor bindingISOJ:164563
Molecular FunctionGO:0046875ephrin receptor bindingIPIJ:177164
Molecular FunctionGO:0005154epidermal growth factor receptor bindingISOJ:155856
Molecular FunctionGO:0005158insulin receptor bindingISOJ:164563
Molecular FunctionGO:0005159insulin-like growth factor receptor bindingISOJ:164563
Molecular FunctionGO:0005168neurotrophin TRKA receptor bindingISOJ:164563
Molecular FunctionGO:0051219phosphoprotein bindingISOJ:155856
Molecular FunctionGO:0001784phosphotyrosine bindingISOJ:155856
Molecular FunctionGO:0005515protein bindingIPIJ:85624
Molecular FunctionGO:0005515protein bindingIPIJ:113920
Molecular FunctionGO:0005515protein bindingIPIJ:114108
Molecular FunctionGO:0005515protein bindingIPIJ:133325
Molecular FunctionGO:0005515protein bindingIPIJ:200359
Molecular FunctionGO:0005515protein bindingIPIJ:200360
Molecular FunctionGO:0005515protein bindingIPIJ:200379
Molecular FunctionGO:0005515protein bindingIPIJ:200409
Molecular FunctionGO:0032403protein complex bindingISOJ:155856
Molecular FunctionGO:0030971receptor tyrosine kinase bindingIPIJ:130626
Molecular FunctionGO:0030971receptor tyrosine kinase bindingISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0010008endosome membraneISOJ:155856
Cellular ComponentGO:0005739mitochondrionIEAJ:60000
Cellular ComponentGO:0005634nucleusISOJ:155856
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0070435Shc-EGFR complexISOJ:155856
Biological ProcessGO:0030036actin cytoskeleton organizationISOJ:155856
Biological ProcessGO:0031532actin cytoskeleton reorganizationIMPJ:62182
Biological ProcessGO:0000187activation of MAPK activityIMPJ:62182
Biological ProcessGO:0000187activation of MAPK activityISOJ:155856
Biological ProcessGO:0000187activation of MAPK activityISOJ:164563
Biological ProcessGO:0007568agingISOJ:155856
Biological ProcessGO:0001525angiogenesisIMPJ:62182
Biological ProcessGO:0016337cell-cell adhesionIMPJ:62182
Biological ProcessGO:0007507heart developmentIMPJ:62182
Biological ProcessGO:0008286insulin receptor signaling pathwayISOJ:155856
Biological ProcessGO:0035556intracellular signal transductionIEAJ:72247
Biological ProcessGO:0000165MAPK cascadeISOJ:164563
Biological ProcessGO:0030182neuron differentiationISOJ:155856
Biological ProcessGO:0031175neuron projection developmentISOJ:155856
Biological ProcessGO:0045740positive regulation of DNA replicationISOJ:155856
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationISOJ:155856
Biological ProcessGO:0045907positive regulation of vasoconstrictionISOJ:155856
Biological ProcessGO:0040008regulation of growthIEAJ:60000

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory