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GO Annotations Graph
 Symbol
Name
ID
Il6
interleukin 6
MGI:96559

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Fri Jan 17 13:56:29 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005125cytokine activityIDAJ:771
Molecular FunctionGO:0005125cytokine activityIDAJ:85159
Molecular FunctionGO:0005125cytokine activityISOJ:155856
Molecular FunctionGO:0005125cytokine activityISOJ:164563
Molecular FunctionGO:0008083growth factor activityISOJ:164563
Molecular FunctionGO:0005138interleukin-6 receptor bindingIDAJ:1806
Molecular FunctionGO:0005138interleukin-6 receptor bindingISOJ:155856
Molecular FunctionGO:0005138contributes_to
interleukin-6 receptor binding
ISOJ:164563
Molecular FunctionGO:0005138interleukin-6 receptor bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:47849
Molecular FunctionGO:0005102receptor bindingISOJ:155856
Cellular ComponentGO:0005623cellIMPJ:139138
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:68367
Cellular ComponentGO:0005576extracellular regionIEAJ:60000
Cellular ComponentGO:0005576extracellular regionIEAJ:72247
Cellular ComponentGO:0005615extracellular spaceIDAJ:762
Cellular ComponentGO:0005615extracellular spaceIDAJ:66835
Cellular ComponentGO:0005615extracellular spaceIDAJ:75400
Cellular ComponentGO:0005615extracellular spaceIDAJ:76115
Cellular ComponentGO:0005615extracellular spaceIDAJ:84679
Cellular ComponentGO:0005615extracellular spaceIDAJ:88051
Cellular ComponentGO:0005615extracellular spaceIDAJ:91939
Cellular ComponentGO:0005615extracellular spaceIDAJ:93342
Cellular ComponentGO:0005615extracellular spaceIDAJ:96035
Cellular ComponentGO:0005615extracellular spaceIDAJ:102933
Cellular ComponentGO:0005615extracellular spaceIDAJ:117165
Cellular ComponentGO:0005615extracellular spaceIDAJ:126780
Cellular ComponentGO:0005615extracellular spaceIDAJ:132126
Cellular ComponentGO:0005615extracellular spaceIDAJ:138722
Cellular ComponentGO:0005615extracellular spaceIDAJ:143981
Cellular ComponentGO:0005615extracellular spaceIDAJ:147177
Cellular ComponentGO:0005615extracellular spaceISOJ:155856
Cellular ComponentGO:0005615extracellular spaceISOJ:164563
Cellular ComponentGO:0005615extracellular spaceIDAJ:194920
Cellular ComponentGO:0005896interleukin-6 receptor complexISOJ:164563
Biological ProcessGO:0006953acute-phase responseIEAJ:60000
Biological ProcessGO:0060445branching involved in salivary gland morphogenesisIDAJ:68367
Biological ProcessGO:0060445branching involved in salivary gland morphogenesisIMPJ:68367
Biological ProcessGO:0016049cell growthISOJ:155856
Biological ProcessGO:0045454cell redox homeostasisISOJ:155856
Biological ProcessGO:0070301cellular response to hydrogen peroxideISOJ:164563
Biological ProcessGO:0019221cytokine-mediated signaling pathwayISOJ:164563
Biological ProcessGO:0042832defense response to protozoanIMPJ:117115
Biological ProcessGO:0051607defense response to virusISOJ:164563
Biological ProcessGO:0031018endocrine pancreas developmentIMPJ:139138
Biological ProcessGO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIDAJ:68367
Biological ProcessGO:0070091glucagon secretionIMPJ:139138
Biological ProcessGO:0002384hepatic immune responseISOJ:164563
Biological ProcessGO:0006955immune responseIEAJ:72247
Biological ProcessGO:0006954inflammatory responseISOJ:164563
Biological ProcessGO:0070102interleukin-6-mediated signaling pathwayIDAJ:1806
Biological ProcessGO:0070102interleukin-6-mediated signaling pathwayISOJ:164563
Biological ProcessGO:0046716muscle cell cellular homeostasisIGIJ:130429
Biological ProcessGO:0043066negative regulation of apoptotic processISOJ:164563
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:155856
Biological ProcessGO:0045079negative regulation of chemokine biosynthetic processIDAJ:85159
Biological ProcessGO:0045079negative regulation of chemokine biosynthetic processIMPJ:85159
Biological ProcessGO:0032966negative regulation of collagen biosynthetic processISOJ:164563
Biological ProcessGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processISOJ:155856
Biological ProcessGO:0050710negative regulation of cytokine secretionISOJ:155856
Biological ProcessGO:0045721negative regulation of gluconeogenesisISOJ:155856
Biological ProcessGO:0046888negative regulation of hormone secretionIDAJ:23748
Biological ProcessGO:0048635negative regulation of muscle organ developmentISOJ:155856
Biological ProcessGO:1901215negative regulation of neuron deathISOJ:155856
Biological ProcessGO:0006469negative regulation of protein kinase activityISOJ:155856
Biological ProcessGO:0031175neuron projection developmentISOJ:164563
Biological ProcessGO:0001781neutrophil apoptotic processIDAJ:85159
Biological ProcessGO:0001781neutrophil apoptotic processIMPJ:85159
Biological ProcessGO:0001781neutrophil apoptotic processISOJ:164563
Biological ProcessGO:0002675positive regulation of acute inflammatory responseISOJ:164563
Biological ProcessGO:0043065positive regulation of apoptotic processISOJ:164563
Biological ProcessGO:0050871positive regulation of B cell activationISOJ:164563
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:164563
Biological ProcessGO:0032722positive regulation of chemokine productionISOJ:164563
Biological ProcessGO:0045740positive regulation of DNA replicationISOJ:155856
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationIDAJ:68367
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationIMPJ:68367
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeISOJ:155856
Biological ProcessGO:0010628positive regulation of gene expressionISOJ:155856
Biological ProcessGO:0051024positive regulation of immunoglobulin secretionISOJ:164563
Biological ProcessGO:0032755positive regulation of interleukin-6 productionISOJ:164563
Biological ProcessGO:0046427positive regulation of JAK-STAT cascadeISOJ:155856
Biological ProcessGO:0046427positive regulation of JAK-STAT cascadeISOJ:164563
Biological ProcessGO:0043410positive regulation of MAPK cascadeISOJ:73065
Biological ProcessGO:0045666positive regulation of neuron differentiationISOJ:155856
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processISOJ:155856
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylationISOJ:73065
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationISOJ:73065
Biological ProcessGO:0033160positive regulation of protein import into nucleus, translocationISOJ:155856
Biological ProcessGO:0051897positive regulation of protein kinase B signalingISOJ:155856
Biological ProcessGO:0051091positive regulation of sequence-specific DNA binding transcription factor activityISOJ:164563
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationISOJ:164563
Biological ProcessGO:0042102positive regulation of T cell proliferationISOJ:164563
Biological ProcessGO:0045630positive regulation of T-helper 2 cell differentiationIDAJ:81987
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:73065
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIGIJ:151963
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIDAJ:771
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0045727positive regulation of translationISOJ:164563
Biological ProcessGO:0051971positive regulation of transmission of nerve impulseISOJ:155856
Biological ProcessGO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinISOJ:155856
Biological ProcessGO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinISOJ:164563
Biological ProcessGO:0042981regulation of apoptotic processIMPJ:68367
Biological ProcessGO:0042127regulation of cell proliferationIGIJ:130429
Biological ProcessGO:0008360regulation of cell shapeISOJ:155856
Biological ProcessGO:0045188regulation of circadian sleep/wake cycle, non-REM sleepISOJ:155856
Biological ProcessGO:0010574regulation of vascular endothelial growth factor productionISOJ:164563
Biological ProcessGO:0051384response to glucocorticoidISOJ:164563
Biological ProcessGO:0009611response to woundingIDAJ:148250
Biological ProcessGO:0042110T cell activationIGIJ:141227

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory