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GO Annotations Graph
growth differentiation factor 5

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Thu Oct 8 15:06:18 2015.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0036122BMP bindingISOJ:164563
Molecular FunctionGO:0005125cytokine activityIBAJ:161428
Molecular FunctionGO:0008083growth factor activityIEAJ:72247
Molecular FunctionGO:0008083growth factor activityIEAJ:60000
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:87049
Molecular FunctionGO:0005515protein bindingIPIJ:88556
Molecular FunctionGO:0005515protein bindingIPIJ:91306
Molecular FunctionGO:0005102receptor bindingISOJ:155856
Molecular FunctionGO:0005160transforming growth factor beta receptor bindingIBAJ:161428
Cellular ComponentGO:0005576extracellular regionIEAJ:60000
Cellular ComponentGO:0005615extracellular spaceIBAJ:161428
Cellular ComponentGO:0005622intracellularISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005886plasma membraneIEAJ:60000
Biological ProcessGO:0030509BMP signaling pathwayIBAJ:161428
Biological ProcessGO:0051216cartilage developmentIEAJ:60000
Biological ProcessGO:0048468cell developmentIBAJ:161428
Biological ProcessGO:0060591chondroblast differentiationISOJ:164563
Biological ProcessGO:0002062chondrocyte differentiationIGIJ:141606
Biological ProcessGO:0030326embryonic limb morphogenesisIMPJ:94510
Biological ProcessGO:0035136forelimb morphogenesisIMPJ:17582
Biological ProcessGO:0040007growthIEAJ:72247
Biological ProcessGO:0035137hindlimb morphogenesisIMPJ:17582
Biological ProcessGO:0035137hindlimb morphogenesisIMPJ:124813
Biological ProcessGO:0098779mitophagy in response to mitochondrial depolarizationISOJ:164563
Biological ProcessGO:0032331negative regulation of chondrocyte differentiationISOJ:164563
Biological ProcessGO:0050680negative regulation of epithelial cell proliferationISOJ:164563
Biological ProcessGO:2001054negative regulation of mesenchymal cell apoptotic processIMPJ:94510
Biological ProcessGO:0043524negative regulation of neuron apoptotic processISOJ:155856
Biological ProcessGO:0030513positive regulation of BMP signaling pathwayISOJ:164563
Biological ProcessGO:0032332positive regulation of chondrocyte differentiationIDAJ:52419
Biological ProcessGO:0032332positive regulation of chondrocyte differentiationISOJ:164563
Biological ProcessGO:0045666positive regulation of neuron differentiationISOJ:155856
Biological ProcessGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylationIBAJ:161428
Biological ProcessGO:0043408regulation of MAPK cascadeIBAJ:161428
Biological ProcessGO:0040014regulation of multicellular organism growthIMPJ:124813
Biological ProcessGO:0007184SMAD protein import into nucleusISOJ:164563
Biological ProcessGO:0060395SMAD protein signal transductionISOJ:164563
Biological ProcessGO:0060395SMAD protein signal transductionIBAJ:161428
Biological ProcessGO:0007178transmembrane receptor protein serine/threonine kinase signaling pathwayIGIJ:141606

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory