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GO Annotations Graph
 Symbol
Name
ID
Apoe
apolipoprotein E
MGI:88057

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0016209antioxidant activityISOJ:164563
Molecular FunctionGO:0001540beta-amyloid bindingISOJ:155856
Molecular FunctionGO:0001540beta-amyloid bindingISOJ:164563
Molecular FunctionGO:0017127cholesterol transporter activityIDAJ:93331
Molecular FunctionGO:0008201heparin bindingISOJ:164563
Molecular FunctionGO:0046848hydroxyapatite bindingISOJ:155856
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0008289lipid bindingISOJ:164563
Molecular FunctionGO:0005319lipid transporter activityISOJ:155856
Molecular FunctionGO:0005319lipid transporter activityISOJ:164563
Molecular FunctionGO:0071813lipoprotein particle bindingIDAJ:71838
Molecular FunctionGO:0050750low-density lipoprotein particle receptor bindingISOJ:164563
Molecular FunctionGO:0046911metal chelating activityISOJ:164563
Molecular FunctionGO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityIMPJ:150395
Molecular FunctionGO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityISOJ:164563
Molecular FunctionGO:0005543phospholipid bindingISOJ:155856
Molecular FunctionGO:0005543phospholipid bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:193640
Molecular FunctionGO:0042803protein homodimerization activityISOJ:164563
Molecular FunctionGO:0005102receptor bindingISOJ:155856
Molecular FunctionGO:0048156tau protein bindingISOJ:164563
Molecular FunctionGO:0070326very-low-density lipoprotein particle receptor bindingISOJ:164563
Cellular ComponentGO:0072562blood microparticleISOJ:164563
Cellular ComponentGO:0009986cell surfaceISOJ:155856
Cellular ComponentGO:0042627chylomicronISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0030425dendriteISOJ:155856
Cellular ComponentGO:0034365discoidal high-density lipoprotein particleISOJ:155856
Cellular ComponentGO:0005769colocalizes_with
early endosome
ISOJ:155856
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:155856
Cellular ComponentGO:0005768endosomeISOJ:155856
Cellular ComponentGO:0005576extracellular regionIEAJ:60000
Cellular ComponentGO:0005576extracellular regionIEAJ:72247
Cellular ComponentGO:0005615extracellular spaceIDAJ:22362
Cellular ComponentGO:0005615extracellular spaceIDAJ:40819
Cellular ComponentGO:0005615extracellular spaceIDAJ:42632
Cellular ComponentGO:0005615extracellular spaceIDAJ:93331
Cellular ComponentGO:0005615extracellular spaceISOJ:155856
Cellular ComponentGO:0005615extracellular spaceISOJ:164563
Cellular ComponentGO:0070062extracellular vesicular exosomeISOJ:164563
Cellular ComponentGO:0031232extrinsic component of external side of plasma membraneISOJ:155856
Cellular ComponentGO:0005794Golgi apparatusISOJ:155856
Cellular ComponentGO:0034364high-density lipoprotein particleISOJ:164563
Cellular ComponentGO:0034363intermediate-density lipoprotein particleISOJ:164563
Cellular ComponentGO:0005770late endosomeISOJ:155856
Cellular ComponentGO:0034362low-density lipoprotein particleIDAJ:150395
Cellular ComponentGO:0034362low-density lipoprotein particleISOJ:164563
Cellular ComponentGO:0005764lysosomeISOJ:155856
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0005874colocalizes_with
microtubule
ISOJ:155856
Cellular ComponentGO:0043025neuronal cell bodyISOJ:155856
Cellular ComponentGO:0005635nuclear envelopeISOJ:155856
Cellular ComponentGO:0005634nucleusISOJ:164563
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0034361very-low-density lipoprotein particleISOJ:164563
Biological ProcessGO:0007568agingISOJ:155856
Biological ProcessGO:0097113alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringISOJ:164563
Biological ProcessGO:0048844artery morphogenesisIGIJ:116827
Biological ProcessGO:0072358cardiovascular system developmentIMPJ:159593
Biological ProcessGO:0006874cellular calcium ion homeostasisIDAJ:18071
Biological ProcessGO:0019934cGMP-mediated signalingISOJ:164563
Biological ProcessGO:0006707cholesterol catabolic processIMPJ:51282
Biological ProcessGO:0033344cholesterol effluxIMPJ:72104
Biological ProcessGO:0033344cholesterol effluxIDAJ:93331
Biological ProcessGO:0033344cholesterol effluxISOJ:164563
Biological ProcessGO:0042632cholesterol homeostasisIMPJ:2809
Biological ProcessGO:0042632cholesterol homeostasisIMPJ:22362
Biological ProcessGO:0042632cholesterol homeostasisIGIJ:66424
Biological ProcessGO:0042632cholesterol homeostasisIGIJ:116827
Biological ProcessGO:0042632cholesterol homeostasisISOJ:164563
Biological ProcessGO:0008203cholesterol metabolic processIMPJ:2809
Biological ProcessGO:0008203cholesterol metabolic processIMPJ:76988
Biological ProcessGO:0008203cholesterol metabolic processISOJ:164563
Biological ProcessGO:0034382chylomicron remnant clearanceISOJ:164563
Biological ProcessGO:0055089fatty acid homeostasisISOJ:164563
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayISOJ:164563
Biological ProcessGO:0034380high-density lipoprotein particle assemblyISOJ:164563
Biological ProcessGO:0034384high-density lipoprotein particle clearanceISOJ:164563
Biological ProcessGO:0034375high-density lipoprotein particle remodelingISOJ:164563
Biological ProcessGO:0055088lipid homeostasisIMPJ:129977
Biological ProcessGO:0006629lipid metabolic processIGIJ:66424
Biological ProcessGO:0006869lipid transportISOJ:155856
Biological ProcessGO:0042158lipoprotein biosynthetic processIGIJ:121045
Biological ProcessGO:0042159lipoprotein catabolic processIMPJ:129977
Biological ProcessGO:0042157lipoprotein metabolic processIMPJ:51022
Biological ProcessGO:0042157lipoprotein metabolic processIGIJ:66424
Biological ProcessGO:0042157lipoprotein metabolic processIGIJ:87974
Biological ProcessGO:0042157lipoprotein metabolic processISOJ:155856
Biological ProcessGO:0015909long-chain fatty acid transportISOJ:164563
Biological ProcessGO:0034374low-density lipoprotein particle remodelingIMPJ:150395
Biological ProcessGO:0051651maintenance of location in cellIMPJ:129977
Biological ProcessGO:0097114N-methyl-D-aspartate receptor clusteringISOJ:164563
Biological ProcessGO:1902430negative regulation of beta-amyloid formationISOJ:164563
Biological ProcessGO:0030195negative regulation of blood coagulationISOJ:164563
Biological ProcessGO:0043537negative regulation of blood vessel endothelial cell migrationISOJ:164563
Biological ProcessGO:0045541negative regulation of cholesterol biosynthetic processISOJ:164563
Biological ProcessGO:0090370negative regulation of cholesterol effluxISOJ:164563
Biological ProcessGO:0061000negative regulation of dendritic spine developmentISOJ:164563
Biological ProcessGO:1902951negative regulation of dendritic spine maintenanceISOJ:164563
Biological ProcessGO:0001937negative regulation of endothelial cell proliferationISOJ:164563
Biological ProcessGO:0050728negative regulation of inflammatory responseIGIJ:179147
Biological ProcessGO:0051055negative regulation of lipid biosynthetic processISOJ:164563
Biological ProcessGO:1903001negative regulation of lipid transport across blood brain barrierISOJ:164563
Biological ProcessGO:0043407negative regulation of MAP kinase activityISOJ:164563
Biological ProcessGO:0043524negative regulation of neuron apoptotic processISOJ:155856
Biological ProcessGO:1901215negative regulation of neuron deathISOJ:164563
Biological ProcessGO:1902999negative regulation of phospholipid effluxISOJ:164563
Biological ProcessGO:0010544negative regulation of platelet activationISOJ:164563
Biological ProcessGO:1901627negative regulation of postsynaptic membrane organizationISOJ:164563
Biological ProcessGO:1901630negative regulation of presynaptic membrane organizationISOJ:164563
Biological ProcessGO:0007263nitric oxide mediated signal transductionISOJ:164563
Biological ProcessGO:0033700phospholipid effluxISOJ:164563
Biological ProcessGO:0045773positive regulation of axon extensionISOJ:155856
Biological ProcessGO:1902004positive regulation of beta-amyloid formationISOJ:164563
Biological ProcessGO:0043085positive regulation of catalytic activityIMPJ:150395
Biological ProcessGO:0030828positive regulation of cGMP biosynthetic processISOJ:164563
Biological ProcessGO:0010875positive regulation of cholesterol effluxISOJ:164563
Biological ProcessGO:0010873positive regulation of cholesterol esterificationIMPJ:150395
Biological ProcessGO:0010873positive regulation of cholesterol esterificationISOJ:164563
Biological ProcessGO:0060999positive regulation of dendritic spine developmentISOJ:164563
Biological ProcessGO:1902952positive regulation of dendritic spine maintenanceISOJ:164563
Biological ProcessGO:0046889positive regulation of lipid biosynthetic processISOJ:164563
Biological ProcessGO:1903002positive regulation of lipid transport across blood brain barrierISOJ:164563
Biological ProcessGO:0032805positive regulation of low-density lipoprotein particle receptor catabolic processISOJ:164563
Biological ProcessGO:0051044positive regulation of membrane protein ectodomain proteolysisISOJ:164563
Biological ProcessGO:1902998positive regulation of neurofibrillary tangle assemblyISOJ:164563
Biological ProcessGO:1901216positive regulation of neuron deathISOJ:164563
Biological ProcessGO:0051000positive regulation of nitric-oxide synthase activityISOJ:164563
Biological ProcessGO:1902995positive regulation of phospholipid effluxISOJ:164563
Biological ProcessGO:1901628positive regulation of postsynaptic membrane organizationISOJ:164563
Biological ProcessGO:1901631positive regulation of presynaptic membrane organizationISOJ:164563
Biological ProcessGO:0017038protein importISOJ:164563
Biological ProcessGO:0006898receptor-mediated endocytosisISOJ:164563
Biological ProcessGO:1900221regulation of beta-amyloid clearanceISOJ:164563
Biological ProcessGO:0032489regulation of Cdc42 protein signal transductionISOJ:164563
Biological ProcessGO:0010468regulation of gene expressionIMPJ:129977
Biological ProcessGO:1901214regulation of neuron deathISOJ:164563
Biological ProcessGO:1902947regulation of tau-protein kinase activityISOJ:164563
Biological ProcessGO:0002021response to dietary excessIMPJ:129977
Biological ProcessGO:0006979response to oxidative stressIMPJ:33429
Biological ProcessGO:0043691reverse cholesterol transportISOJ:164563
Biological ProcessGO:0006810transportIEAJ:60000
Biological ProcessGO:0006641triglyceride metabolic processISOJ:164563
Biological ProcessGO:0042311vasodilationIMPJ:51282
Biological ProcessGO:0034447very-low-density lipoprotein particle clearanceISOJ:164563
Biological ProcessGO:0034372very-low-density lipoprotein particle remodelingIMPJ:150395
Biological ProcessGO:0034372very-low-density lipoprotein particle remodelingISOJ:164563

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory