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GO Annotations Graph
adrenergic receptor, alpha 2a

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0004935adrenergic receptor activityIMPJ:105642
Molecular FunctionGO:0031696alpha-2C adrenergic receptor bindingISOJ:164563
Molecular FunctionGO:0004938alpha2-adrenergic receptor activityTASJ:77486
Molecular FunctionGO:0004938alpha2-adrenergic receptor activityISOJ:155856
Molecular FunctionGO:0004938alpha2-adrenergic receptor activityISOJ:164563
Molecular FunctionGO:0051379epinephrine bindingISOJ:164563
Molecular FunctionGO:0004930G-protein coupled receptor activityIEAJ:60000
Molecular FunctionGO:0032795heterotrimeric G-protein bindingISOJ:164563
Molecular FunctionGO:0051380norepinephrine bindingISOJ:164563
Molecular FunctionGO:0046982protein heterodimerization activityISOJ:164563
Molecular FunctionGO:0042803protein homodimerization activityISOJ:164563
Molecular FunctionGO:0019901protein kinase bindingISOJ:164563
Molecular FunctionGO:0004871signal transducer activityIEAJ:60000
Molecular FunctionGO:0031996thioesterase bindingISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0005887integral component of plasma membraneISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0043235receptor complexISOJ:164563
Cellular ComponentGO:0045202synapseISOJ:155856
Biological ProcessGO:0071883activation of MAPK activity by adrenergic receptor signaling pathwayISOJ:164563
Biological ProcessGO:0032147activation of protein kinase activityISOJ:164563
Biological ProcessGO:0032148activation of protein kinase B activityISOJ:164563
Biological ProcessGO:0002526acute inflammatory responseISOJ:155856
Biological ProcessGO:0071881adenylate cyclase-inhibiting adrenergic receptor signaling pathwayISOJ:164563
Biological ProcessGO:0071875adrenergic receptor signaling pathwayIMPJ:105642
Biological ProcessGO:0032870cellular response to hormone stimulusISOJ:164563
Biological ProcessGO:0006260DNA replicationISOJ:155856
Biological ProcessGO:0035625epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayISOJ:164563
Biological ProcessGO:0042596fear responseIMPJ:89367
Biological ProcessGO:0007565female pregnancyISOJ:155856
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayIDAJ:105642
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayISOJ:155856
Biological ProcessGO:0042593glucose homeostasisISOJ:155856
Biological ProcessGO:0042593glucose homeostasisISOJ:164563
Biological ProcessGO:0045955negative regulation of calcium ion-dependent exocytosisISOJ:155856
Biological ProcessGO:0030818negative regulation of cAMP biosynthetic processISOJ:164563
Biological ProcessGO:0046676negative regulation of insulin secretionISOJ:164563
Biological ProcessGO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulusISOJ:155856
Biological ProcessGO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulusISOJ:164563
Biological ProcessGO:0050995negative regulation of lipid catabolic processISOJ:164563
Biological ProcessGO:0070473negative regulation of uterine smooth muscle contractionISOJ:155856
Biological ProcessGO:0071882phospholipase C-activating adrenergic receptor signaling pathwayISOJ:164563
Biological ProcessGO:0030335positive regulation of cell migrationISOJ:164563
Biological ProcessGO:0001819positive regulation of cytokine productionISOJ:164563
Biological ProcessGO:0045741positive regulation of epidermal growth factor-activated receptor activityISOJ:164563
Biological ProcessGO:0043406positive regulation of MAP kinase activityISOJ:164563
Biological ProcessGO:0051044positive regulation of membrane protein ectodomain proteolysisISOJ:164563
Biological ProcessGO:0045909positive regulation of vasodilationISOJ:155856
Biological ProcessGO:0090303positive regulation of wound healingISOJ:164563
Biological ProcessGO:0007165signal transductionIEAJ:60000
Biological ProcessGO:0050955thermoceptionISOJ:155856

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory