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GO Annotations Graph
 Symbol
Name
ID
Tlr2
toll-like receptor 2
MGI:1346060

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0042498diacyl lipopeptide bindingIDAJ:156189
Molecular FunctionGO:0042498diacyl lipopeptide bindingIDAJ:158053
Molecular FunctionGO:0071723lipopeptide bindingISOJ:155856
Molecular FunctionGO:0070891lipoteichoic acid bindingIDAJ:156189
Molecular FunctionGO:0042834peptidoglycan bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:169893
Molecular FunctionGO:0046982protein heterodimerization activityIPIJ:156189
Molecular FunctionGO:0046982protein heterodimerization activityISOJ:158053
Molecular FunctionGO:0004872receptor activityISOJ:164563
Molecular FunctionGO:0008329signaling pattern recognition receptor activityISOJ:164563
Molecular FunctionGO:0004888transmembrane signaling receptor activityIEAJ:72247
Molecular FunctionGO:0042497triacyl lipopeptide bindingISOJ:158053
Molecular FunctionGO:0042497triacyl lipopeptide bindingIDAJ:158053
Cellular ComponentGO:0044297cell bodyISOJ:155856
Cellular ComponentGO:0042995cell projectionISOJ:155856
Cellular ComponentGO:0009986cell surfaceISOJ:155856
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0031410cytoplasmic vesicleIEAJ:60000
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:91804
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0016021integral component of membraneIEAJ:72247
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005886plasma membraneIDAJ:89998
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0035354Toll-like receptor 1-Toll-like receptor 2 protein complexISOJ:158053
Cellular ComponentGO:0035355Toll-like receptor 2-Toll-like receptor 6 protein complexIPIJ:156189
Biological ProcessGO:0002752cell surface pattern recognition receptor signaling pathwayIMPJ:89998
Biological ProcessGO:0071221cellular response to bacterial lipopeptideIMPJ:96018
Biological ProcessGO:0071221cellular response to bacterial lipopeptideTASJ:161025
Biological ProcessGO:0071726cellular response to diacyl bacterial lipopeptideISOJ:73065
Biological ProcessGO:0071223cellular response to lipoteichoic acidISOJ:73065
Biological ProcessGO:0071223cellular response to lipoteichoic acidIMPJ:96018
Biological ProcessGO:0071224cellular response to peptidoglycanIMPJ:113450
Biological ProcessGO:0071727cellular response to triacyl bacterial lipopeptideISOJ:73065
Biological ProcessGO:0032289central nervous system myelin formationISOJ:155856
Biological ProcessGO:0042892chloramphenicol transportIMPJ:95726
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIMPJ:96018
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIMPJ:106736
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIMPJ:147177
Biological ProcessGO:0050830defense response to Gram-positive bacteriumISOJ:164563
Biological ProcessGO:0042496detection of diacyl bacterial lipopeptideISOJ:73065
Biological ProcessGO:0042495detection of triacyl bacterial lipopeptideISOJ:73065
Biological ProcessGO:0007252I-kappaB phosphorylationISOJ:164563
Biological ProcessGO:0006955immune responseIEAJ:72247
Biological ProcessGO:0002376immune system processIEAJ:60000
Biological ProcessGO:0052063induction by symbiont of defense-related host nitric oxide productionIMPJ:104231
Biological ProcessGO:0006954inflammatory responseISOJ:155856
Biological ProcessGO:0045087innate immune responseTASJ:161025
Biological ProcessGO:0006691leukotriene metabolic processISOJ:155856
Biological ProcessGO:0001774microglial cell activationISOJ:155856
Biological ProcessGO:0002755MyD88-dependent toll-like receptor signaling pathwayIGIJ:89998
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:155856
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostIMPJ:96018
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostIMPJ:106736
Biological ProcessGO:0032695negative regulation of interleukin-12 productionIMPJ:113450
Biological ProcessGO:0032700negative regulation of interleukin-17 productionIMPJ:104231
Biological ProcessGO:0046209nitric oxide metabolic processISOJ:155856
Biological ProcessGO:0032722positive regulation of chemokine productionIMPJ:104231
Biological ProcessGO:0032722positive regulation of chemokine productionISOJ:164563
Biological ProcessGO:0050715positive regulation of cytokine secretionIGIJ:153503
Biological ProcessGO:0050729positive regulation of inflammatory responseIEAJ:72247
Biological ProcessGO:0032728positive regulation of interferon-beta productionIDAJ:161025
Biological ProcessGO:0032733positive regulation of interleukin-10 productionISOJ:155856
Biological ProcessGO:0032735positive regulation of interleukin-12 productionIDAJ:161025
Biological ProcessGO:0032741positive regulation of interleukin-18 productionIDAJ:161025
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIMPJ:76115
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIMPJ:106736
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIDAJ:132126
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIDAJ:161025
Biological ProcessGO:0032755positive regulation of interleukin-6 productionISOJ:164563
Biological ProcessGO:0032757positive regulation of interleukin-8 productionISOJ:164563
Biological ProcessGO:0002687positive regulation of leukocyte migrationIMPJ:140680
Biological ProcessGO:0060907positive regulation of macrophage cytokine productionIMPJ:76115
Biological ProcessGO:0042346positive regulation of NF-kappaB import into nucleusISOJ:164563
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityISOJ:73065
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processIMPJ:76115
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processIMPJ:104231
Biological ProcessGO:0051770positive regulation of nitric-oxide synthase biosynthetic processIDAJ:161025
Biological ProcessGO:0048714positive regulation of oligodendrocyte differentiationISOJ:155856
Biological ProcessGO:0034123positive regulation of toll-like receptor signaling pathwayISOJ:164563
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:161025
Biological ProcessGO:0042535positive regulation of tumor necrosis factor biosynthetic processIMPJ:104231
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:76115
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:89998
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:96018
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:104231
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:106736
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIDAJ:161025
Biological ProcessGO:0030177positive regulation of Wnt signaling pathwayISOJ:164563
Biological ProcessGO:0050707regulation of cytokine secretionIEAJ:72247
Biological ProcessGO:0032493response to bacterial lipoproteinISOJ:155856
Biological ProcessGO:0009617response to bacteriumIMPJ:140680
Biological ProcessGO:0070542response to fatty acidISOJ:155856
Biological ProcessGO:0002237response to molecule of bacterial originIEAJ:72247
Biological ProcessGO:0002238response to molecule of fungal originIMPJ:89998
Biological ProcessGO:0032494response to peptidoglycanIMPJ:76115
Biological ProcessGO:0032494response to peptidoglycanIMPJ:140680
Biological ProcessGO:0007165signal transductionIEAJ:72247
Biological ProcessGO:0034134toll-like receptor 2 signaling pathwayIEAJ:72247
Biological ProcessGO:0002224toll-like receptor signaling pathwayISOJ:155856

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory