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GO Annotations Graph
Niemann-Pick type C1

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Thu Oct 8 15:06:18 2015.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0015485cholesterol bindingISOJ:164563
Molecular FunctionGO:0008158hedgehog receptor activityIEAJ:72247
Molecular FunctionGO:0005515protein bindingIPIJ:110348
Molecular FunctionGO:0005515protein bindingIPIJ:180176
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:164563
Cellular ComponentGO:0005768endosomeIDAJ:110348
Cellular ComponentGO:0005768endosomeIDAJ:120537
Cellular ComponentGO:0070062extracellular exosomeISOJ:164563
Cellular ComponentGO:0005576extracellular regionIDAJ:180176
Cellular ComponentGO:0005794Golgi apparatusIDAJ:120537
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0016021integral component of membraneIEAJ:72247
Cellular ComponentGO:0005887integral component of plasma membraneISOJ:164563
Cellular ComponentGO:0005765lysosomal membraneISOJ:164563
Cellular ComponentGO:0005764lysosomeIDAJ:180176
Cellular ComponentGO:0005764lysosomeIDAJ:120537
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0016020membraneIDAJ:120537
Cellular ComponentGO:0045121membrane raftIDAJ:120537
Cellular ComponentGO:0005635nuclear envelopeISOJ:164563
Cellular ComponentGO:0005635nuclear envelopeIDAJ:160544
Cellular ComponentGO:0048471perinuclear region of cytoplasmISOJ:164563
Cellular ComponentGO:0005886plasma membraneIDAJ:120537
Cellular ComponentGO:0031982vesicleIDAJ:120537
Biological ProcessGO:0007628adult walking behaviorIGIJ:145003
Biological ProcessGO:0006914autophagyISOJ:145003
Biological ProcessGO:0071404cellular response to low-density lipoprotein particle stimulusIDAJ:120537
Biological ProcessGO:0071383cellular response to steroid hormone stimulusIDAJ:120537
Biological ProcessGO:0033344cholesterol effluxISOJ:164563
Biological ProcessGO:0033344cholesterol effluxIMPJ:120283
Biological ProcessGO:0042632cholesterol homeostasisISOJ:164563
Biological ProcessGO:0008203cholesterol metabolic processIEAJ:60000
Biological ProcessGO:0030301cholesterol transportISOJ:164563
Biological ProcessGO:0006897endocytosisIMPJ:91039
Biological ProcessGO:0090150establishment of protein localization to membraneISOJ:164563
Biological ProcessGO:0006629lipid metabolic processIEAJ:60000
Biological ProcessGO:0031579membrane raft organizationISOJ:164563
Biological ProcessGO:0060548negative regulation of cell deathISOJ:155856
Biological ProcessGO:0016242negative regulation of macroautophagyIGIJ:125097
Biological ProcessGO:0016242negative regulation of macroautophagyIMPJ:125097
Biological ProcessGO:2000189positive regulation of cholesterol homeostasisISOJ:164563
Biological ProcessGO:0006486protein glycosylationISOJ:164563
Biological ProcessGO:0006486protein glycosylationIDAJ:180176
Biological ProcessGO:0046686response to cadmium ionISOJ:155856
Biological ProcessGO:0042493response to drugIDAJ:120537
Biological ProcessGO:0008202steroid metabolic processIEAJ:60000
Biological ProcessGO:0046718viral entry into host cellIMPJ:176235
Biological ProcessGO:0046718viral entry into host cellISOJ:164563
Biological ProcessGO:0046718viral entry into host cellIMPJ:219073

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.02
The Jackson Laboratory