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GO Annotations Graph
 Symbol
Name
ID
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B
MGI:109323

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Wed Jul 23 12:17:05 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0008144drug bindingIDAJ:163130
Molecular FunctionGO:0008144drug bindingISOJ:164563
Molecular FunctionGO:0001965G-protein alpha-subunit bindingISOJ:164563
Molecular FunctionGO:0004930G-protein coupled receptor activityIEAJ:60000
Molecular FunctionGO:0004930G-protein coupled receptor activityIEAJ:72247
Molecular FunctionGO:0005099Ras GTPase activator activityIMPJ:39559
Molecular FunctionGO:0051378serotonin bindingISOJ:31112
Molecular FunctionGO:0051378serotonin bindingIDAJ:163130
Molecular FunctionGO:0051378serotonin bindingISOJ:164563
Molecular FunctionGO:0004993serotonin receptor activityISOJ:31112
Molecular FunctionGO:0004993serotonin receptor activityTASJ:64067
Molecular FunctionGO:0004993serotonin receptor activityIDAJ:163130
Molecular FunctionGO:0004993serotonin receptor activityISOJ:164563
Molecular FunctionGO:0004871signal transducer activityIEAJ:60000
Cellular ComponentGO:0030054cell junctionIEAJ:60000
Cellular ComponentGO:0005737cytoplasmIDAJ:163130
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0016021integral component of membraneIEAJ:72247
Cellular ComponentGO:0005887integral component of plasma membraneIEAJ:72247
Cellular ComponentGO:0005622intracellularIMPJ:39559
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0043005neuron projectionIEAJ:60000
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0005886plasma membraneIDAJ:163130
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0045202synapseIEAJ:60000
Biological ProcessGO:0007202activation of phospholipase C activityISOJ:164563
Biological ProcessGO:0007610behaviorIEAJ:60000
Biological ProcessGO:0019722calcium-mediated signalingISOJ:164563
Biological ProcessGO:0003300cardiac muscle hypertrophyIMPJ:156435
Biological ProcessGO:0006874cellular calcium ion homeostasisISOJ:164563
Biological ProcessGO:0071502cellular response to temperature stimulusIDAJ:163130
Biological ProcessGO:0006182cGMP biosynthetic processISOJ:164563
Biological ProcessGO:0048598embryonic morphogenesisIMPJ:40606
Biological ProcessGO:0070371ERK1 and ERK2 cascadeIMPJ:39559
Biological ProcessGO:0070371ERK1 and ERK2 cascadeIMPJ:161157
Biological ProcessGO:0070371ERK1 and ERK2 cascadeISOJ:164563
Biological ProcessGO:0002031G-protein coupled receptor internalizationIDAJ:163130
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayISOJ:164563
Biological ProcessGO:0007507heart developmentIMPJ:64067
Biological ProcessGO:0003007heart morphogenesisIMPJ:40606
Biological ProcessGO:0014827intestine smooth muscle contractionISOJ:164563
Biological ProcessGO:0043066negative regulation of apoptotic processIMPJ:40606
Biological ProcessGO:0010507negative regulation of autophagyISOJ:164563
Biological ProcessGO:0060548negative regulation of cell deathISOJ:164563
Biological ProcessGO:0014033neural crest cell differentiationIMPJ:40606
Biological ProcessGO:0001755neural crest cell migrationIMPJ:40606
Biological ProcessGO:0014065phosphatidylinositol 3-kinase signalingISOJ:164563
Biological ProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayTASJ:64067
Biological ProcessGO:0016310phosphorylationISOJ:164563
Biological ProcessGO:0051781positive regulation of cell divisionIMPJ:39559
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:164563
Biological ProcessGO:0001819positive regulation of cytokine productionISOJ:164563
Biological ProcessGO:0050715positive regulation of cytokine secretionIMPJ:156435
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationIMPJ:162980
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationISOJ:164563
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeISOJ:164563
Biological ProcessGO:0043406positive regulation of MAP kinase activityISOJ:164563
Biological ProcessGO:0051000positive regulation of nitric-oxide synthase activityISOJ:164563
Biological ProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processISOJ:164563
Biological ProcessGO:0032320positive regulation of Ras GTPase activityIMPJ:39559
Biological ProcessGO:0070528protein kinase C signalingISOJ:164563
Biological ProcessGO:0007205protein kinase C-activating G-protein coupled receptor signaling pathwayIMPJ:163130
Biological ProcessGO:0050795regulation of behaviorISOJ:164563
Biological ProcessGO:0050795regulation of behaviorIMPJ:167209
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolISOJ:164563
Biological ProcessGO:0042493response to drugIDAJ:163130
Biological ProcessGO:0042493response to drugISOJ:164563
Biological ProcessGO:0007210serotonin receptor signaling pathwayIDAJ:163130
Biological ProcessGO:0007210serotonin receptor signaling pathwayISOJ:164563
Biological ProcessGO:0007165signal transductionIEAJ:60000
Biological ProcessGO:0006939smooth muscle contractionIEAJ:72247
Biological ProcessGO:0042310vasoconstrictionISOJ:164563

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory