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GO Annotations Graph
 Symbol
Name
ID
Tnf
tumor necrosis factor
MGI:104798

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
  • Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
  • Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
  • Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
  • Graph generated Fri Jan 17 13:56:29 2014.

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005125cytokine activityIDAJ:72219
Molecular FunctionGO:0005125cytokine activityIDAJ:75400
Molecular FunctionGO:0005125cytokine activityISOJ:164563
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0002020protease bindingISOJ:164563
Molecular FunctionGO:0002020protease bindingIPIJ:169801
Molecular FunctionGO:0005515protein bindingIPIJ:108710
Molecular FunctionGO:0044212transcription regulatory region DNA bindingISOJ:164563
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingTASJ:4753
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingIPIJ:11207
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingTASJ:14424
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingTASJ:17976
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingTASJ:41992
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingTASJ:42508
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingTASJ:43602
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingTASJ:47428
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingIDAJ:72219
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingISOJ:155856
Molecular FunctionGO:0005164tumor necrosis factor receptor bindingISOJ:164563
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:103845
Cellular ComponentGO:0009897external side of plasma membraneIDAJ:173331
Cellular ComponentGO:0005576extracellular regionIEAJ:60000
Cellular ComponentGO:0005576extracellular regionIEAJ:72247
Cellular ComponentGO:0005615extracellular spaceIDAJ:762
Cellular ComponentGO:0005615extracellular spaceIDAJ:58383
Cellular ComponentGO:0005615extracellular spaceIDAJ:63492
Cellular ComponentGO:0005615extracellular spaceIDAJ:67213
Cellular ComponentGO:0005615extracellular spaceISOJ:73065
Cellular ComponentGO:0005615extracellular spaceIDAJ:75400
Cellular ComponentGO:0005615extracellular spaceIDAJ:76115
Cellular ComponentGO:0005615extracellular spaceIDAJ:84679
Cellular ComponentGO:0005615extracellular spaceIDAJ:84896
Cellular ComponentGO:0005615extracellular spaceIDAJ:88051
Cellular ComponentGO:0005615extracellular spaceIDAJ:91804
Cellular ComponentGO:0005615extracellular spaceIDAJ:94032
Cellular ComponentGO:0005615extracellular spaceIDAJ:102933
Cellular ComponentGO:0005615extracellular spaceIDAJ:104231
Cellular ComponentGO:0005615extracellular spaceIDAJ:117165
Cellular ComponentGO:0005615extracellular spaceIDAJ:126780
Cellular ComponentGO:0005615extracellular spaceIDAJ:132126
Cellular ComponentGO:0005615extracellular spaceIDAJ:143168
Cellular ComponentGO:0005615extracellular spaceISOJ:155856
Cellular ComponentGO:0016021integral component of membraneISOJ:155856
Cellular ComponentGO:0005887integral component of plasma membraneTASJ:47673
Cellular ComponentGO:0005887integral component of plasma membraneISOJ:164563
Cellular ComponentGO:0005622intracellularIGIJ:114498
Cellular ComponentGO:0005622intracellularIDAJ:152384
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0016020membraneIEAJ:72247
Cellular ComponentGO:0045121membrane raftIDAJ:143672
Cellular ComponentGO:0045121membrane raftISOJ:164563
Cellular ComponentGO:0001891phagocytic cupIDAJ:103845
Cellular ComponentGO:0005886plasma membraneIDAJ:91786
Cellular ComponentGO:0055037recycling endosomeIDAJ:103845
Cellular ComponentGO:0030141secretory granuleTASJ:47673
Biological ProcessGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIDAJ:101402
Biological ProcessGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processISOJ:164563
Biological ProcessGO:0000187activation of MAPK activityISOJ:164563
Biological ProcessGO:0000185activation of MAPKKK activityISOJ:164563
Biological ProcessGO:0006915apoptotic processISOJ:155856
Biological ProcessGO:0097190apoptotic signaling pathwayIDAJ:18874
Biological ProcessGO:0097190apoptotic signaling pathwayIDAJ:95351
Biological ProcessGO:0019722calcium-mediated signalingISOJ:155856
Biological ProcessGO:0001775cell activationISOJ:155856
Biological ProcessGO:0008283cell proliferationTASJ:28061
Biological ProcessGO:0008652cellular amino acid biosynthetic processIDAJ:113782
Biological ProcessGO:0045123cellular extravasationIDAJ:83226
Biological ProcessGO:0071230cellular response to amino acid stimulusIDAJ:164409
Biological ProcessGO:0071316cellular response to nicotineISOJ:164563
Biological ProcessGO:0071407cellular response to organic cyclic compoundISOJ:164563
Biological ProcessGO:0002439chronic inflammatory response to antigenic stimulusISOJ:164563
Biological ProcessGO:0006952defense responseIMPJ:14424
Biological ProcessGO:0006952defense responseIMPJ:41992
Biological ProcessGO:0042742defense response to bacteriumIDAJ:63492
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIGIJ:115034
Biological ProcessGO:0050966detection of mechanical stimulus involved in sensory perception of painISOJ:155856
Biological ProcessGO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIDAJ:67809
Biological ProcessGO:0030198extracellular matrix organizationIDAJ:93921
Biological ProcessGO:0097191extrinsic apoptotic signaling pathwayISOJ:164563
Biological ProcessGO:0097191extrinsic apoptotic signaling pathwayIGIJ:200967
Biological ProcessGO:0097191extrinsic apoptotic signaling pathwayIGIJ:202809
Biological ProcessGO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIGIJ:88139
Biological ProcessGO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIGIJ:156541
Biological ProcessGO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIGIJ:156541
Biological ProcessGO:0008625extrinsic apoptotic signaling pathway via death domain receptorsISOJ:164563
Biological ProcessGO:0006006glucose metabolic processIDAJ:77479
Biological ProcessGO:0006959humoral immune responseIMPJ:47673
Biological ProcessGO:0006955immune responseIEAJ:72247
Biological ProcessGO:0006954inflammatory responseTASJ:4753
Biological ProcessGO:0006954inflammatory responseTASJ:17976
Biological ProcessGO:0006954inflammatory responseISOJ:164563
Biological ProcessGO:0006954inflammatory responseIGIJ:168000
Biological ProcessGO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIDAJ:121372
Biological ProcessGO:0007254JNK cascadeIGIJ:114498
Biological ProcessGO:0050900leukocyte migrationIDAJ:88722
Biological ProcessGO:0050901leukocyte tethering or rollingISOJ:164563
Biological ProcessGO:0031663lipopolysaccharide-mediated signaling pathwayISOJ:164563
Biological ProcessGO:0000165MAPK cascadeISOJ:164563
Biological ProcessGO:0007275multicellular organismal developmentIMPJ:43602
Biological ProcessGO:0097527necroptotic signaling pathwayISOJ:164563
Biological ProcessGO:0097527necroptotic signaling pathwayIGIJ:170814
Biological ProcessGO:0097527necroptotic signaling pathwayIGIJ:180684
Biological ProcessGO:0097527necroptotic signaling pathwayIGIJ:182381
Biological ProcessGO:0097527necroptotic signaling pathwayIGIJ:182381
Biological ProcessGO:0097527necroptotic signaling pathwayIGIJ:200967
Biological ProcessGO:0070265necrotic cell deathISOJ:164563
Biological ProcessGO:0010693negative regulation of alkaline phosphatase activityIDAJ:175244
Biological ProcessGO:0061048negative regulation of branching involved in lung morphogenesisISOJ:164563
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:155856
Biological ProcessGO:0002740negative regulation of cytokine secretion involved in immune responseISOJ:164563
Biological ProcessGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandISOJ:164563
Biological ProcessGO:0010629negative regulation of gene expressionISOJ:164563
Biological ProcessGO:0046325negative regulation of glucose importIDAJ:77479
Biological ProcessGO:0046325negative regulation of glucose importISOJ:155856
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostIGIJ:115034
Biological ProcessGO:0032715negative regulation of interleukin-6 productionISOJ:164563
Biological ProcessGO:0002037negative regulation of L-glutamate transportISOJ:155856
Biological ProcessGO:0050995negative regulation of lipid catabolic processISOJ:164563
Biological ProcessGO:0045668negative regulation of osteoblast differentiationIDAJ:175244
Biological ProcessGO:0043242negative regulation of protein complex disassemblyISOJ:164563
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIDAJ:43208
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterISOJ:164563
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIDAJ:175244
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0045071negative regulation of viral genome replicationISOJ:164563
Biological ProcessGO:0009887organ morphogenesisIMPJ:47673
Biological ProcessGO:0030316osteoclast differentiationIGIJ:95156
Biological ProcessGO:0045760positive regulation of action potentialISOJ:155856
Biological ProcessGO:0043065positive regulation of apoptotic processISOJ:155856
Biological ProcessGO:0043065positive regulation of apoptotic processISOJ:164563
Biological ProcessGO:0060559positive regulation of calcidiol 1-monooxygenase activityISOJ:164563
Biological ProcessGO:0008284positive regulation of cell proliferationTASJ:17976
Biological ProcessGO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 productionISOJ:164563
Biological ProcessGO:0045080positive regulation of chemokine biosynthetic processISOJ:164563
Biological ProcessGO:0032722positive regulation of chemokine productionISOJ:164563
Biological ProcessGO:0002876positive regulation of chronic inflammatory response to antigenic stimulusIGIJ:115034
Biological ProcessGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic processISOJ:164563
Biological ProcessGO:0001819positive regulation of cytokine productionISOJ:164563
Biological ProcessGO:0050715positive regulation of cytokine secretionISOJ:164563
Biological ProcessGO:0031622positive regulation of fever generationIDAJ:155398
Biological ProcessGO:0051798positive regulation of hair follicle developmentIMPJ:108710
Biological ProcessGO:0034116positive regulation of heterotypic cell-cell adhesionISOJ:164563
Biological ProcessGO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulinIGIJ:115034
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDAJ:89322
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDAJ:102721
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIGIJ:102721
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingISOJ:155856
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingISOJ:164563
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDAJ:202809
Biological ProcessGO:0050729positive regulation of inflammatory responseISOJ:155856
Biological ProcessGO:0032729positive regulation of interferon-gamma productionIGIJ:115034
Biological ProcessGO:0032741positive regulation of interleukin-18 productionISOJ:155856
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIDAJ:75400
Biological ProcessGO:0045416positive regulation of interleukin-8 biosynthetic processISOJ:164563
Biological ProcessGO:0046330positive regulation of JNK cascadeIDAJ:102721
Biological ProcessGO:0046330positive regulation of JNK cascadeIGIJ:102721
Biological ProcessGO:0046330positive regulation of JNK cascadeIDAJ:156541
Biological ProcessGO:0043507positive regulation of JUN kinase activityISOJ:164563
Biological ProcessGO:0043406positive regulation of MAP kinase activityISOJ:164563
Biological ProcessGO:0051044positive regulation of membrane protein ectodomain proteolysisISOJ:164563
Biological ProcessGO:0045840positive regulation of mitosisISOJ:155856
Biological ProcessGO:0043525positive regulation of neuron apoptotic processISOJ:155856
Biological ProcessGO:0042346positive regulation of NF-kappaB import into nucleusISOJ:164563
Biological ProcessGO:0042346positive regulation of NF-kappaB import into nucleusIMPJ:175244
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityISOJ:97353
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityISOJ:164563
Biological ProcessGO:0051533positive regulation of NFAT protein import into nucleusISOJ:73065
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processISOJ:164563
Biological ProcessGO:0045672positive regulation of osteoclast differentiationISOJ:164563
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylationISOJ:164563
Biological ProcessGO:0071803positive regulation of podosome assemblyISOJ:164563
Biological ProcessGO:0043068positive regulation of programmed cell deathISOJ:164563
Biological ProcessGO:0031334positive regulation of protein complex assemblyISOJ:164563
Biological ProcessGO:0043243positive regulation of protein complex disassemblyISOJ:164563
Biological ProcessGO:0051897positive regulation of protein kinase B signalingIDAJ:156541
Biological ProcessGO:2000010positive regulation of protein localization to cell surfaceISOJ:164563
Biological ProcessGO:0001934positive regulation of protein phosphorylationISOJ:164563
Biological ProcessGO:0051222positive regulation of protein transportISOJ:155856
Biological ProcessGO:0051222positive regulation of protein transportISOJ:164563
Biological ProcessGO:0051091positive regulation of sequence-specific DNA binding transcription factor activityISOJ:164563
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationISOJ:164563
Biological ProcessGO:0050806positive regulation of synaptic transmissionISOJ:155856
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:43208
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:73065
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:126723
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIDAJ:148250
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIGIJ:155210
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIDAJ:103090
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0045994positive regulation of translational initiation by ironIDAJ:72219
Biological ProcessGO:0060557positive regulation of vitamin D biosynthetic processISOJ:164563
Biological ProcessGO:0000060protein import into nucleus, translocationISOJ:164563
Biological ProcessGO:0043491protein kinase B signalingISOJ:164563
Biological ProcessGO:0032800receptor biosynthetic processISOJ:164563
Biological ProcessGO:0060693regulation of branching involved in salivary gland morphogenesisIDAJ:67809
Biological ProcessGO:0060693regulation of branching involved in salivary gland morphogenesisIMPJ:67809
Biological ProcessGO:0042127regulation of cell proliferationIDAJ:75464
Biological ProcessGO:0043122regulation of I-kappaB kinase/NF-kappaB signalingISOJ:164563
Biological ProcessGO:0051023regulation of immunoglobulin secretionIDAJ:86592
Biological ProcessGO:0050796regulation of insulin secretionISOJ:164563
Biological ProcessGO:0045670regulation of osteoclast differentiationIDAJ:81173
Biological ProcessGO:0001932regulation of protein phosphorylationIDAJ:91027
Biological ProcessGO:0050708regulation of protein secretionIDAJ:149618
Biological ProcessGO:2000377regulation of reactive oxygen species metabolic processIDAJ:182381
Biological ProcessGO:0051384response to glucocorticoidISOJ:164563
Biological ProcessGO:0009615response to virusISOJ:164563
Biological ProcessGO:0030730sequestering of triglycerideISOJ:164563
Biological ProcessGO:0007165signal transductionISOJ:155856
Biological ProcessGO:0006927transformed cell apoptotic processTASJ:17976
Biological ProcessGO:0006927transformed cell apoptotic processTASJ:28061
Biological ProcessGO:0006927transformed cell apoptotic processTASJ:43602
Biological ProcessGO:0006927transformed cell apoptotic processISOJ:164563
Biological ProcessGO:0033209tumor necrosis factor-mediated signaling pathwayIDAJ:15363
Biological ProcessGO:0033209tumor necrosis factor-mediated signaling pathwayISOJ:164563

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral seqeuence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IEP Inferred from expression pattern
  IGC Inferred from genomic context
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  ISO Inferred from sequence orthology
  ISS Inferred from sequence or structural similarity
  NAS Non-traceable Author Statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement
  NR Obsolete Evidence Code: Not Recorded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory