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Phenotype Images associated with this Gene
Symbol
Name
ID
Six1
sine oculis-related homeobox 1
MGI:102780


9 phenotype image(s) for Six1 alleles
Showing image(s) 1 to 9

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Click on allele symbol for full phenotype details.

Caption: Perturbed myogenic differentiation of Six1tm2.1Mair/Six1tm2.1Mair Pax7tm1(cre/ERT2)Gaka/Pax7+ satellite cell descendants ex vivo (details)
Represented Alleles:
Pax7tm1(cre/ERT2)Gaka, paired box 7; targeted mutation 1, Gabrielle Kardon
Six1tm2.1Mair, sine oculis-related homeobox 1; targeted mutation 2.1, Pascal Maire
Copyright: This image is from Le Grand F, J Cell Biol 2012 Sep 3;198(5):815-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:190460
Caption: Perturbed myogenic differentiation of Six1tm2.1Mair/Six1tm2.1Mair Pax7tm1(cre/ERT2)Gaka/Pax7+ satellite cell descendants ex vivo (details)
Represented Alleles:
Pax7tm1(cre/ERT2)Gaka, paired box 7; targeted mutation 1, Gabrielle Kardon
Six1tm2.1Mair, sine oculis-related homeobox 1; targeted mutation 2.1, Pascal Maire
Copyright: This image is from Le Grand F, J Cell Biol 2012 Sep 3;198(5):815-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:190460
Caption: Impaired skeletal muscle regeneration in Six1tm2.1Mair/Six1tm2.1Mair Pax7tm1(cre/ERT2)Gaka/Pax7+ mice (details)
Represented Alleles:
Pax7tm1(cre/ERT2)Gaka, paired box 7; targeted mutation 1, Gabrielle Kardon
Six1tm2.1Mair, sine oculis-related homeobox 1; targeted mutation 2.1, Pascal Maire
Copyright: This image is from Le Grand F, J Cell Biol 2012 Sep 3;198(5):815-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:190460
Caption: Impaired tissue repair in regenerated Six1tm2.1Mair/Six1tm2.1Mair Pax7tm1(cre/ERT2)Gaka/Pax7+ muscles (details)
Represented Alleles:
Pax7tm1(cre/ERT2)Gaka, paired box 7; targeted mutation 1, Gabrielle Kardon
Six1tm2.1Mair, sine oculis-related homeobox 1; targeted mutation 2.1, Pascal Maire
Copyright: This image is from Le Grand F, J Cell Biol 2012 Sep 3;198(5):815-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:190460
Caption: (A-F) Gross morphological defects of the outflow tract and great arteries of newborn mutants (B-F) versus wild-type control (A). (G-J) H&E histological staining of sectioned hearts revealed VSD and dysmorphology of the outflow valves in a Six1tm1Mair/Six1tm1Mair Eya1tm1Rilm/Eya1tm1Rilm mutant compared with control (details)
Represented Alleles:
Eya1tm1Rilm, EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
Six1tm1Mair, sine oculis-related homeobox 1; targeted mutation 1, Pascal Maire
Copyright: This image is from Guo C, J Clin Invest 2011 Apr 1;121(4):1585-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172023
Caption: TUNEL staining of sagittal sections from control and Six1tm1Mair/Six1tm1MairEya1tm1Rilm/Eya1tm1Rilm revealed increased cell death in pharyngeal endoderm, SHF/splanchnic mesoderm, and pharyngeal mesenchyme that contained cardiac neural crest cells and mesoderm (details)
Represented Alleles:
Eya1tm1Rilm, EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
Six1tm1Mair, sine oculis-related homeobox 1; targeted mutation 1, Pascal Maire
Copyright: This image is from Guo C, J Clin Invest 2011 Apr 1;121(4):1585-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172023
Caption: (A-H) Six1tm1Mair/Six1tm1Mair Eya1tm1Rilm/Eya1tm1Rilm mutants (E-H) had hypoplastic outflow tract cushions compared with wild-type littermate controls (A-D) (details)
Represented Alleles:
Eya1tm1Rilm, EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
Six1tm1Mair, sine oculis-related homeobox 1; targeted mutation 1, Pascal Maire
Tbx1tm1Bem, T-box 1; targeted mutation 1, Bernice E Morrow
Copyright: This image is from Guo C, J Clin Invest 2011 Apr 1;121(4):1585-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172023
Caption: (A-F) Alizarin red (bone) and alcian blue (cartilage) staining of newborn Six1tm1Mair/Six1tm1MairEya1tm1Rilm/Eya1tm1Rilm mutants reveal abnormal facial structures. (G-N) MF20 immunohistochemical staining (red) of skeletal muscle demonstrates hypoplastic branchiomeric skeletal muscles (details)
Represented Alleles:
Eya1tm1Rilm, EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
Six1tm1Mair, sine oculis-related homeobox 1; targeted mutation 1, Pascal Maire
Tbx1tm1Bem, T-box 1; targeted mutation 1, Bernice E Morrow
Copyright: This image is from Guo C, J Clin Invest 2011 Apr 1;121(4):1585-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172023
Caption: Newborn Fgf8tm1Moon/Fgf8tm1MoonSix1tm1(cre,ALPP)Xli/Six1+ mutants exhibit interrupted aortic arch-type B and vascular ring (details)
Represented Alleles:
Fgf8tm1.3Mrt, fibroblast growth factor 8; targeted mutation 1.3, Gail R Martin
Six1tm1(cre,ALPP)Xli, sine oculis-related homeobox 1; targeted mutation 1, Xue Li
Copyright: This image is from Guo C, J Clin Invest 2011 Apr 1;121(4):1585-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172023

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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory