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Phenotype Images associated with this Gene
Symbol
Name
ID
Six2
sine oculis-related homeobox 2
MGI:102778


10 phenotype image(s) for Six2 alleles
Showing image(s) 1 to 10

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Click on allele symbol for full phenotype details.

Caption: Abnormal kidney development in Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ (details)
Represented Alleles:
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Yap1tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: Abnormal nephron formation in Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice (details)
Represented Alleles:
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Yap1tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: Impaired nephron induction in Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice (details)
Represented Alleles:
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Yap1tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: S-shaped body is reduced in size in Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ nephrons (details)
Represented Alleles:
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Yap1tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: Kidney abnormalities in Cdc42tm1Brak/Cdc42tm1Brak Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice (details)
Represented Alleles:
Cdc42tm1Brak, cell division cycle 42; targeted mutation 1, Cord Brakebusch
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: Nephrogenesis abnormalities in Wwtr1tm1Hmc/Wwtr1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+, Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ and double mutant mice (details)
Represented Alleles:
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Wwtr1tm1Hmc, WW domain containing transcription regulator 1; targeted mutation 1, Helen McNeill
Yap1tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: Kidney development abnormalities in Cdc42tm1Brak/Cdc42tm1Brak Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice (details)
Represented Alleles:
Cdc42tm1Brak, cell division cycle 42; targeted mutation 1, Cord Brakebusch
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: Hypoplasia and loss of glomeruli and proximal tubules in Wasltm2Sbs/Wasltm2Sbs Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ kidneys (details)
Represented Alleles:
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Wasltm2Sbs, WASP like actin nucleation promoting factor; targeted mutation 2, Scott B Snapper
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: Loss of foot processes in Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice (details)
Represented Alleles:
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Yap1tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266
Caption: Decreased branching morphogenesis in Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ kidneys (details)
Represented Alleles:
Six2tm1(tTA,tetO-EGFP/cre)Amc, sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Yap1tm1Hmc, yes-associated protein 1; targeted mutation 1, Helen McNeill
Copyright: This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory