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Phenotype Images associated with this Allele
Nomenclature
Symbol: Acvrl1tm2.1Spo
Name: activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
MGI ID: MGI:4398901
Synonyms: Alk11f/2f, Alk12loxP
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Arteriovenous malformations in the brain, lung, and GI tract of Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Acvrl1-cre)L1Spo/0		involves: 129 * FVB
Internal bleeding and anemia, and hemorrhages in the lung and GI tract in tamoxifen treated Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+		involves: 129 * 129S1/Sv * 129X1/SvJ
Wounding can induce de novo arteriovenous malformation in Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ adult miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+		involves: 129 * 129S1/Sv * 129X1/SvJ
Wound-induced arteriovenous malformation development in adult subdermal vessels in Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+		involves: 129 * 129S1/Sv * 129X1/SvJ
Blood flow through patent arteriovenous fistulas in Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+		involves: 129 * 129S1/Sv * 129X1/SvJ
Cerebral arteriovenous malformations in Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Acvrl1-cre)L1Spo/0		involves: 129 * FVB
Pulmonary arteriovenous malformations in Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Acvrl1-cre)L1Spo/0		involves: 129 * FVB
Enlarged heart in tamoxifen-treated Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+		involves: 129 * 129S1/Sv * 129X1/SvJ
Hemorrhages and vascular malformation in the lungs and GI tract of tamoxifen-treated adult Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ miceAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+		involves: 129 * 129S1/Sv * 129X1/SvJ
Uterine arteriovenous malformations in tamoxifen-treated adult Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ Alk1 mutantsAcvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+		involves: 129 * 129S1/Sv * 129X1/SvJ
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory