Phenotype Image Detail

Image

Caption

Intravital images of vascular morphogenesis responding to wound in wild-type and Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ mice. The wound was induced and tamoxifen (TM) given on day 0. The center of the wound is indicated by an asterisk. Representative bright-field images of blood vessels of a control (B) and a mutant (C) mouse during wound healing for 8 days. Corresponding pseudocolor images of Hb(O2) saturation levels on the blood vessels of a control (A) and a mutant (D) mouse are shown. Arteries are distinguished from veins by their thin morphology and a high level of Hb saturation (red) at day 1. While such distinctions in major branches remained through 8 days of wound healing in controls (A and B), arteries and veins were almost indistinguishable at days 7-8 in mutant mice due to extensive remodeling and AV shunting (C and D). The color code to the right of D represents the percentage of Hb(O2) saturation [Hb(O2)sat] in the blood vessels. Scale bar (D, day 8): 1 mm.

Copyright

This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620

Associated Alleles

Symbol	Name
Acvrl1^tm2.1Spo	activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
Gt(ROSA)26Sor^tm1(cre/ERT)Nat	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+	involves: 129 * 129S1/Sv * 129X1/SvJ