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Phenotype Images associated with this Allele
Nomenclature
Symbol: Epn2tm1Ocr
Name: epsin 2; targeted mutation 1, Ottavio Cremona
MGI ID: MGI:4356016
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Disrupted endothelial junctions in tumor vessels of Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 miceEpn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0		involves: 129X1/SvJ * C57BL/6J
Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 and Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre)7Mlia/0 miceEpn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0		involves: 129X1/SvJ * C57BL/6J
Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre)7Mlia/0		involves: C57BL/6J * FVB/N
Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0 miceEpn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
Tg(TRAMP)8247Ng/0		involves: 129X1/SvJ * C57BL/6 * C57BL/6J
Increased tumor vessel permeability in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 miceEpn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0		involves: 129X1/SvJ * C57BL/6J
Major developmental defects in Epn1tm1Ocr/Epn1tm1Ocr Epn2tm1Ocr/Epn2tm1Ocr embryosEpn1tm1Ocr/Epn1tm1Ocr
Epn2tm1Ocr/Epn2tm1Ocr		B6.129X1-Epn1tm1Ocr Epn2tm1Ocr
Heart abnormalities in Epn1tm1Ocr/Epn1tm1Ocr Epn2tm1Ocr/Epn2tm1Ocr miceEpn1tm1Ocr/Epn1tm1Ocr
Epn2tm1Ocr/Epn2tm1Ocr		B6.129X1-Epn1tm1Ocr Epn2tm1Ocr
Developmental defects in the placenta and yolk sac of Epn1tm1Ocr/Epn1tm1Ocr Epn2tm1Ocr/Epn2tm1Ocr miceEpn1tm1Ocr/Epn1tm1Ocr
Epn2tm1Ocr/Epn2tm1Ocr		B6.129X1-Epn1tm1Ocr Epn2tm1Ocr
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory