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Phenotype Images associated with this Allele
Nomenclature
Symbol: Gata4tm1.1Wtp
Name: GATA binding protein 4; targeted mutation 1.1, William T Pu
MGI ID: MGI:3526854
Synonyms: Gata4flox
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Hypocellular endocardial cushions in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Tek-cre)1Ywa/0 miceGata4tm1Grg/Gata4tm1.1Wtp
Tg(Tek-cre)1Ywa/0		involves: 129 * C57BL/6 * SJL
Hearts of Gata4tm1.1Wtp/Gata4tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normalGata4tm1Grg/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0		involves: 129 * C57BL/6 * FVB/N
Growth retardation and myocardial thinning in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Nkx2-5-cre)9Eno/0 miceGata4tm1Grg/Gata4tm1.1Wtp
Tg(Nkx2-5-cre)9Eno/0		involves: 129 * C57BL/6
Reduced coronary microvasculature, decreased capillary density and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 heartsGata4tm1Sho/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0		involves: 129S6/SvEvTac * 129S7/SvEvBrd
Edema, peripheral hemorrhage, and reduced coronary plexus in Gata4tm1.1Wtp/Gata4tm1Sho Nkx2-5tm1(cre)Rjs/Nkx2-5+ embryos and enlarged dilated ventricles and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 heartsGata4tm1Sho/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+		involves: 129S6/SvEvTac * 129S7/SvEvBrd
Gata4tm1Sho/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0		involves: 129S6/SvEvTac * 129S7/SvEvBrd
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory