Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Lyn^tm1Sor
Name:	LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:1861966
Synonyms:	Lyn-

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
		Allelic Composition	Genetic Background
	Lupus-like autoimmune disease in Lyn^tm1Sor/Lyn^tm1Sor and Lyn^tm1.1Calo/Lyn^tm1.1Calo Top2a^{Gt(PST14568)Mfgc}/0 mice	Lyn^tm1Sor/Lyn^tm1Sor	involves: 129S4/SvJaeSor
		Lyn^tm1.1Calo/Lyn^tm1.1Calo Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA
	By 8 months, severe leukocyte infiltration is seen in the lungs, liver and skin of Lyn^tm1Sor/Lyn^tm1Sor mice but not Lyn^tm1.1Calo/Lyn^tm1.1Calo Tg(Itgax-cre)1-1Reiz/0 mice	Lyn^tm1Sor/Lyn^tm1Sor	involves: 129S4/SvJaeSor
		Lyn^tm1.1Calo/Lyn^tm1.1Calo Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA
	Splenomegaly and lymphadenopathy in Lyn^tm1Sor/Lyn^tm1Sor and Lyn^tm1.1Calo/Lyn^tm1.1Calo Tg(Itgax-cre)1-1Reiz/0 mice	Lyn^tm1Sor/Lyn^tm1Sor	involves: 129S4/SvJaeSor
		Lyn^tm1.1Calo/Lyn^tm1.1Calo Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA

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