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Phenotype Image Detail
Image
Caption A-C: Appearance of control (CT) (A), Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (Rxralpha beta ep-/-) (B), and Rxratm1Ipc/Rxratm4Ipc Rxrbtm1Mma/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (RXRalpha betaepaf2o)(C) mice at week 5. Close views of the ears are shown in Insets. Black arrows in B and C point to regions with hair loss, and white arrowhead in B Inset points to the red and swollen ear. D-F: Hematoxylin and eosin staining of ear sections of CT (D), Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (E), and Rxratm1Ipc/Rxratm4Ipc Rxrbtm1Mma/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (F) at week 5. White arrows point to dermal-epidermal junction. hf, hair follicle; u, utriculi. Scale bar 50um.
Copyright This image is from Li M, Proc Natl Acad Sci U S A 2005 Oct 11;102(41):14795-800. Copyright 2005 National Academy of Sciences, U.S.A. J:102470
Associated
Alleles
Symbol Name
Rxratm1Ipc retinoid X receptor alpha; targeted mutation 1, Pierre Chambon
Rxratm4Ipc retinoid X receptor alpha; targeted mutation 4, Pierre Chambon
Rxrbtm1Mma retinoid X receptor beta; targeted mutation 1, Manuel Mark
Rxrbtm1Pcn retinoid X receptor beta; targeted mutation 1, Pierre Chambon
Tg(KRT14-cre/ERT2)1Ipc transgene insertion 1, I Pierre Chambon
Associated
Genotypes
Allelic Composition Genetic Background
Rxratm4Ipc/Rxratm4Ipc
Rxrbtm1Pcn/Rxrbtm1Pcn
Tg(KRT14-cre/ERT2)1Ipc/0 		involves: 129S2/SvPas
Rxratm1Ipc/Rxratm4Ipc
Rxrbtm1Mma/Rxrbtm1Pcn
Tg(KRT14-cre/ERT2)1Ipc/0 		involves: 129S2/SvPas
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory