Phenotype Image Detail

Image

Caption

Purkinje cells (PCs) degenerate over time in Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0 (Afg312^PC-KO) mice. Vibratome sections of the cerebellum were collected at various time points from Afg3l2^tm1Arte/Afg3l2^tm1Arte (Afg312^fl/fl) and Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0 mice and stained for (A-D) calbindin to show progressive PC loss, (E-H) IBA1 to detect resting and activated microglia; and (I-L) glial fibrillary protein (GFAP) to mark reactive astrocytes. Scale bar: 100 um.

This image is from Almajan ER, J Clin Invest 2012 Nov 1;122(11):4048-58 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193564

Associated
Alleles

Symbol	Name
Afg3l2^tm1Arte	AFG3-like AAA ATPase 2; targeted mutation 1, TaconicArtemis
Tg(Pcp2-cre)2Mpin	transgene insertion 2, Max-Planck-Institute of Neurobiology

Associated
Genotypes

Allelic Composition	Genetic Background
Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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