Afg3l2^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Afg3l2^tm1Arte
• Name: AFG3-like AAA ATPase 2; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:5476783
• Synonyms: Afg3l2^fl
• Gene: Afg3l2 Location: Chr18:67537834-67582242 bp, - strand Genetic Position: Chr18, 39.96 cM
• Alliance: Afg3l2^tm1Arte page

Purkinje cell degeneration in Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193564
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 5. (J:193564)

Generation of the Afg3l2^tm1Arte allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Afg3l2 Mutation: 67 strains or lines available

References

• Original: J:193564 Almajan ER, et al., AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival. J Clin Invest. 2012 Nov 1;122(11):4048-58
• All: 6 reference(s)