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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PIK3CA HGNC:8975 (HGNC)
5290 (Entrez Gene)
171834 (OMIM)
HGNC homology
Chr3 q26.3 Chr3:179148114-179240084 (+)
Breast Cancer
Colorectal Cancer; CRC
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi
Cowden Syndrome 5; CWS5
Gastric Cancer
Hepatocellular Carcinoma
Keratosis, Seborrheic
Lung Cancer
Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome; MCAP
Nevus, Epidermal
Ovarian Cancer
P42336 (UniProt | EBI)
NM_006218 (RefSeq)
mouse Pik3ca MGI:1206581 (MGI)
18706 (Entrez Gene)
Gene Tree
Chr3 15.7 cM Chr3:32397671-32466107 (+)
Breast Cancer
Ovarian Cancer
OTTMUSG00000021191 (VEGA)
OTTMUSP00000023403 (VEGA)
OTTMUST00000050202 (VEGA)
rat Pik3ca 170911 (Entrez Gene)
Chr2 q25 A0A0G2K344 (UniProt | EBI)
NM_133399 (RefSeq)
chimpanzee PIK3CA 460858 (Entrez Gene)
Chr3 XP_009445164 (RefSeq)
rhesus macaque PIK3CA 709959 (Entrez Gene)
Chr2 NP_001247597 (RefSeq)
NM_001260668 (RefSeq)
cattle PIK3CA 282306 (Entrez Gene)
Chr1 P32871 (UniProt | EBI)
NM_174574 (RefSeq)
dog PIK3CA 488084 (Entrez Gene)
Chr34 XP_545208 (RefSeq)
chicken PIK3CA 424971 (Entrez Gene)
Chr9 NP_001004410 (RefSeq)
NM_001004410 (RefSeq)
western clawed frog pik3ca 100144924 (Entrez Gene)
ChrUN NP_001119972 (RefSeq)
NM_001126500 (RefSeq)
zebrafish LOC100334726 100334726 (Entrez Gene)
pik3ca 561737 (Entrez Gene)
Chr11 XP_005155911 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory